171734-73-9 Usage
Description
1-(2-bromobenzyl)-1H-indole-3-carboxaldehyde is a chemical compound with the molecular formula C15H11BrNO. It is a derivative of indole, a heterocyclic aromatic organic compound. 1-(2-bromobenzyl)-1H-indole-3-carboxaldehyde features a bromine atom and an aldehyde group attached to the indole ring, along with a benzyl group. Its unique structure and properties make it a versatile building block in organic synthesis and medicinal chemistry research, particularly for the development of indole-based compounds with potential pharmaceutical applications.
Uses
Used in Pharmaceutical Research:
1-(2-bromobenzyl)-1H-indole-3-carboxaldehyde is used as a building block for the synthesis of various indole-based compounds. Its application in pharmaceutical research is due to its potential to be incorporated into new drugs with specific therapeutic properties.
Used in Organic Synthesis:
In the field of organic synthesis, 1-(2-bromobenzyl)-1H-indole-3-carboxaldehyde serves as a key intermediate for creating a range of complex organic molecules. Its utility stems from the presence of the bromine atom, which can be used for further functionalization, and the aldehyde group, which is a versatile handle for chemical reactions.
Used in Medicinal Chemistry:
1-(2-bromobenzyl)-1H-indole-3-carboxaldehyde is used as a starting material in medicinal chemistry to develop new drugs. The indole core is a common structural motif in many bioactive molecules, and the presence of the bromine and benzyl groups in this compound allows for the fine-tuning of its biological activity and pharmacokinetic properties.
Used in Chemical Research:
1-(2-bromobenzyl)-1H-indole-3-carboxaldehyde is also utilized in chemical research to study the reactivity of different functional groups and to explore novel reaction pathways. Its unique structure makes it an interesting subject for academic research and the development of new synthetic methods.
Check Digit Verification of cas no
The CAS Registry Mumber 171734-73-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,1,7,3 and 4 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 171734-73:
(8*1)+(7*7)+(6*1)+(5*7)+(4*3)+(3*4)+(2*7)+(1*3)=139
139 % 10 = 9
So 171734-73-9 is a valid CAS Registry Number.
171734-73-9Relevant articles and documents
Synthesis, characterization, and biological evaluation of indole aldehydes containing N-benzyl moiety
Survase, Dattatray N.,Karhale, Shrikrishna S.,Khedkar, Vijay M.,Helavi, Vasant B.
, p. 3486 - 3497 (2019/11/11)
The present study describes the synthesis, characterization and biological evaluation of N-benzyl indole aldehydes. The biological activities of the newly synthesized compounds were examined by investigating their antioxidant and anti-inflammatory activities. The potential of these compounds as an antioxidant was determined by 2,2-diphenylpicrylhydrazyl, Nitric oxide, Superoxide, peroxide radical scavenging methods. We found that aldehydes 4a, 4b, 4c, and 4e and shows promising in vitro DPPH scavenging antioxidant activity while aldehyde 4b and 4e show good in vitro anti-inflammatory activity.
Synthesis and anti-proliferative activity of aromatic substituted 5-((1-benzyl-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H) -trione analogs against human tumor cell lines
Madadi, Nikhil Reddy,Penthala, Narsimha Reddy,Janganati, Venumadhav,Crooks, Peter A.
, p. 601 - 603 (2014/01/23)
Based on previous SAR studies on N-benzylindole and barbituric acid hybrid molecules, we have synthesized a series of aromatic substituted 5-((1-benzyl-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H) -trione analogs (3a-i) and evaluated th
Aplysinopsin analogs: Synthesis and anti-proliferative activity of substituted (Z)-5-(N-benzylindol-3-ylmethylene)imidazolidine-2,4-diones
Thirupathi Reddy,Narsimha Reddy,Koduru, Srinivas,Damodaran, Chendil,Crooks, Peter A.
scheme or table, p. 3570 - 3574 (2010/07/17)
A series of substituted (Z)-5-(N-benzylindol-3-ylmethylene)imidazolidine-2,4-dione (3) analogs structurally related to aplysinopsin, and that incorporate a variety of substituents in both the indole and N-benzyl moieties have been synthesized under microwave irradiation and conventional heating methods These analogs were evaluated for their anti-proliferative activity against MCF-7 and MDA-231 breast cancer cell lines, and A549 and H460 lung cancer cell lines. Two analogs, 3f and 3j had IC50 values of 4.4 and 5.2 μM, respectively, compared to 5-fluorouracil (IC50 = 15.2 μM) against MCF-7 cells.
