173173-55-2

Basic information

• Product Name: 3',3-dichloro-4',4-dihydroxy-5',5-bis(hydroxymethyl)-1,1-diphenylmethane
• Synonyms: 3',3-dichloro-4',4-dihydroxy-5',5-bis(hydroxymethyl)-1,1-diphenylmethane
• CAS NO: 173173-55-2
• Molecular Weight: 329.18
• Mol File: 173173-55-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3',3-dichloro-4',4-dihydroxy-5',5-bis(hydroxymethyl)-1,1-diphenylmethane(CAS DataBase Reference)
• NIST Chemistry Reference: 3',3-dichloro-4',4-dihydroxy-5',5-bis(hydroxymethyl)-1,1-diphenylmethane(173173-55-2)
• EPA Substance Registry System: 3',3-dichloro-4',4-dihydroxy-5',5-bis(hydroxymethyl)-1,1-diphenylmethane(173173-55-2)

Safety Data

• Hazardous Substances Data: 173173-55-2(Hazardous Substances Data)

Upstream product

• 95-57-8 2-monochlorophenol 
• 50-00-0 formaldehyd 
• 2787-77-1 4,4′-methylenebis(2-chlorophenol) 
• 128626-47-1 3,3'-dichloro-5,5'-dicarboxy-4,4'-dihydroxydiphenylmethane 
• 22471-02-9 2-chloro-6-(hydroxymethyl)phenol 

Relevant articles and documents

Correlation of anti-HIV potency with lipophilicity in a series of cosalane analogs having normal alkenyl and phosphodiester chains as cholestane replacements

In order to define the role of the cholestane moiety in the anti-HIV agent cosalane, a series of cosalane analogs was synthesized in which the cholestane ring system was replaced by normal alkenyl and phosphodiester substituents having varied chain lengths and lipophilicities. The compounds containing simple alkenyl substituents were found to be more potent as inhibitors of the cytopathic effect of HIV-1 in cell culture than the phosphodiesters. In addition, the potencies of the alkene congeners correlated positively with chain length and lipophilicity of the alkene. The results indicate that the cholestane moiety of cosalane functions as a lipophilic accessory appendage to escort the dichlorodisalicylmethane pharmacophore to a lipid environment.