174464-21-2Relevant articles and documents
Synthesis of anisolylated aspartyl and glutamyl tripeptides
Berree, Fabienne,Chang, Kieyoung,Cobas, Agustin,Rapoport, Henry
, p. 715 - 721 (2007/10/03)
A process has been developed for transforming the β-carboxyl of aspartate and the γ-carboxyl of glutamate into anisolyl ketones. These ketones are occasional byproducts in peptide synthesis, resulting from deprotection or resin-removal processes in the presence of anisole as a scavenger. The ketone amino acids have been incorporated in a tripeptide by coupling with CBMIT. During peptide bond formation the keto group of the glutamyl residue required protection, which was provided as the ethylene dithioketal.