174736-11-9

Basic information

• Product Name: N-((R)-1-{2-[(S)-2-(4-Methoxy-phenyl)-2-oxo-ethanesulfinyl]-phenyl}-ethyl)-2,2-dimethyl-propionamide
• Synonyms: N-((R)-1-{2-[(S)-2-(4-Methoxy-phenyl)-2-oxo-ethanesulfinyl]-phenyl}-ethyl)-2,2-dimethyl-propionamide
• CAS NO: 174736-11-9
• Molecular Weight: 401.527
• Mol File: 174736-11-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-((R)-1-{2-[(S)-2-(4-Methoxy-phenyl)-2-oxo-ethanesulfinyl]-phenyl}-ethyl)-2,2-dimethyl-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-((R)-1-{2-[(S)-2-(4-Methoxy-phenyl)-2-oxo-ethanesulfinyl]-phenyl}-ethyl)-2,2-dimethyl-propionamide(174736-11-9)
• EPA Substance Registry System: N-((R)-1-{2-[(S)-2-(4-Methoxy-phenyl)-2-oxo-ethanesulfinyl]-phenyl}-ethyl)-2,2-dimethyl-propionamide(174736-11-9)

Safety Data

• Hazardous Substances Data: 174736-11-9(Hazardous Substances Data)

Upstream product

• 139343-81-0 (S_(S)R)-(+)-3-methyl-2-pivaloyl-2,3-dihydroisothiazole 1-oxide 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Relevant articles and documents

Recoverable chiral sulfoxides for asymmetric synthesis: application to stereoselective carbonyl reduction and the asymmetric synthesis of allylic alcohols

The enantiomerically pure cyclic sulfinamide S(S)R-(+)-3 reacts with the sodium enolates of ketones to give the corresponding homochiral sulfoxides.Reduction of the carbonyl group in these products may be achieved using a variety of reducing agents the best of which were DIBAL-H or DIBAL-H/ZnBr2, which give complementary products of high diastereomeric excess.Reduction of the hydroxy sulfoxides with Raney nickel proceeds in low yield and causes partial racemisation of the products.However the combined use of a durected reduction followed by a facile sulfenic acid elimination provides a synthesis of allylic alcohols in high enentiomeric excess.