17494-29-0

Basic information

• Product Name: Morpholine, 4-[(4-methoxyphenyl)methyl]-
• CAS NO: 17494-29-0
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.272
• Mol File: 17494-29-0.mol
• Article Data: 41

Chemical Properties

• CAS DataBase Reference: Morpholine, 4-[(4-methoxyphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Morpholine, 4-[(4-methoxyphenyl)methyl]-(17494-29-0)
• EPA Substance Registry System: Morpholine, 4-[(4-methoxyphenyl)methyl]-(17494-29-0)

Safety Data

• Hazardous Substances Data: 17494-29-0(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 2746-25-0 p-Methoxybenzyl bromide 
• 4394-85-8 4-morpholinecarboxaldehyde 
• 824-94-2 p-methoxybenzyl chloride 
• 18811-63-7 N-(ethoxymethyl)morpholine 
• 70744-47-7 (p-methoxyphenyl)tri-n-butylstannane 
• 940-00-1 (4-methoxyphenyl)trimethylstannane 
• 201230-82-2 carbon monoxide 
• 105-13-5 4-Methoxybenzyl alcohol 
• 7504-58-7 N-(4-methoxybenzoyl)morpholine 
• 2393-23-9 4-methoxy-benzylamine 
• 623-12-1 4-chloromethoxybenzene 
• 1268340-94-8 (morpholinium-4-ylmethyl)trifluoroborate internal salt 
• 50-00-0 formaldehyd 

Downstream Products

• 202822-78-4 2-Methoxy-5-(4-morpholinylmethyl)benzenemethanol 
• 202822-83-1 3-[[2-methoxy-5-(4-morpholinylmethyl)phenyl]methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-(3H)-one 
• 570398-19-5 4-(p-methoxybenzyl)morpholin-3-one 

Relevant articles and documents

Carbon monoxide-driven osmium catalyzed reductive amination harvesting WGSR power

Herein, we present the first example of Os-catalyzed efficient reductive amination under water-gas shift reaction conditions. The developed catalytic systems are formedin situin aqueous solutions, employ as small as 0.0625 mol% osmium and are capable of delivering reductive amination products for a broad range of aliphatic and aromatic carbonyl compounds and amines. The scope of the reaction, active catalytic systems, possible limitations of the method and DFT-supported mechanistic considerations are discussed in detail in the manuscript.

An Efficient Palladium-Catalysed Aminocarbonylation of Benzyl Chlorides

An improved procedure for the aminocarbonylation of benzyl chloride derivatives using carbon monoxide and either primary or secondary amines has been developed. Studying the competing background alkylation reaction allowed the solvent and base to be selected for a simple catalyst screen, which, in turn, enabled the discovery of a method for the preparation of 2-arylacetamides under mild conditions, with minimal side-products using an inexpensive phosphine ligand. This non-traditional optimisation strategy allowed us to overcome the background alkylation, which has been cited as justification for the development of more complex and less atom-economical approaches.

Thioglycerol-Stabilized Rhodium Nanoparticles in Biphasic Medium as Catalysts in Multistep Reactions

Small rhodium nanoparticles (ca. 3.5 nm) were prepared by the decomposition of an organometallic precursor under hydrogen pressure in glycerol using 1-thioglycerol as stabilizer. Full characterization in the solid state [HR-TEM, EDX, XPS] showed a fcc structure for the Rh0/RhI nanoparticles capped with thiolate ligand. Reduction of different functionalities, including nitro groups and imines, was applied to tandem reductive amination of aldehydes with primary and secondary amines, and to the synthesis of N-substituted anilines from nitrobenzene. In addition, thiolate-capped RhNPs could be recovered and reused up to 5 runs without loss of activity nor selectivity.