176391-61-0

Basic information

• Product Name: 1-bromo-4-isopropoxy-2-methoxybenzene
• Synonyms: 1-bromo-4-isopropoxy-2-methoxybenzene
• CAS NO: 176391-61-0
• Molecular Weight: 245.116
• Mol File: 176391-61-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1-bromo-4-isopropoxy-2-methoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-4-isopropoxy-2-methoxybenzene(176391-61-0)
• EPA Substance Registry System: 1-bromo-4-isopropoxy-2-methoxybenzene(176391-61-0)

Safety Data

• Hazardous Substances Data: 176391-61-0(Hazardous Substances Data)

Usage

Structure

Benzene ring with a bromine atom, an isopropoxy group, and a methoxy group as substituents

Usage

Intermediate in organic synthesis (pharmaceuticals, agrochemicals, dyes), biological activity, potential medicinal properties, production of polymers, reagent in chemical reactions

Hazards

Potential hazards and toxic effects, should be handled with caution.

Upstream product

• 75-30-9 2-iodo-propane 
• 102127-34-4 4-bromo-3-methoxyphenol 
• 584-08-7 potassium carbonate 

Downstream Products

• 176391-62-1 4,5-dihydro-2-<2'-methoxy-4',6-bis(1-methylethoxy)<1,1'-biphenyl>-2-yl>-4,4-dimethyloxazole 
• 199858-09-8 4-isopropoxy-2-methoxyphenylboronic acid 
• 199858-11-2 N,N-diethyl O-[5-isopropoxy-4-methoxy-2-(4-isopropoxy-2-methoxyphenyl)]-1-naphthylcarbamate 

Relevant articles and documents

PIPERIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

The invention relates to new piperidine derivatives of the formula (I) to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

NEW AZIRIDINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS ACETYL-COA CARBOXYLASE INHIBITORS

The invention relates to new azetidine derivatives of the formula (I) wherein Ar1, Ar2, X, R, T and L are as defined in the description, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

Combined directed remote metalation-transition metal catalyzed cross coupling strategies: The total synthesis of the aglycones of the gilvocarcins V, M, and E and arnottin I

(Chemical Equation Presented) A key directed remote metalation (DreM)-carbamoyl migration strategy was applied in an efficient synthesis of the naturally occurring 6H-naphtho[1,2-b]benzopyran-6-one defucogilvocarcin V (1a, Scheme 11). The required biarylcarbamate 33d was best prepared by a high yielding Suzuki coupling reaction of 31a with the differentially protected trioxygenated naphthalene coupling partner 32d which was synthesized using a selective acylation of a juglone derivative. In the late stages of the synthesis, the triflate 39 served as the common intermediate to install the required C-8 vinyl group of 1a (Stille coupling) as well as the required substituents for the preparation of defucogilvocarcins M (1b) and E (1c). A variety of protecting group strategies were investigated and provided insight into which groups are preferred for the DreM-carbamoyl migration process. The strategic lessons learned from this total synthesis were applied in the successful total synthesis of the structurally similar natural product arnottin I (2).