17678-19-2

Basic information

• Product Name: 2-Furylhydroxymethylketone
• Synonyms: 2-Furylhydroxymethylketone;Ethanone, 1-(2-furanyl)-2-hydroxy-;1-(2-Furyl)-2-hydroxyethanone;2-(Hydroxyacetyl)furan;Furyl HydroxyMethyl Ketone;1-(furan-2-yl)-2-hydroxyethanone
• CAS NO: 17678-19-2
• Molecular Formula: C₆H₆O₃
• Molecular Weight: 126.11004
• Product Categories: Aromatics, Heterocycles, Miscellaneous Reagents
• Mol File: 17678-19-2.mol
• Article Data: 33

Chemical Properties

• Melting Point: 112 °C
• Boiling Point: 239.8°Cat760mmHg
• Flash Point: 98.8°C
• Appearance: /
• Density: 1.245g/cm³
• Vapor Pressure: 0.0214mmHg at 25°C
• Refractive Index: 1.506
• PKA: 12.77±0.10(Predicted)
• CAS DataBase Reference: 2-Furylhydroxymethylketone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Furylhydroxymethylketone(17678-19-2)
• EPA Substance Registry System: 2-Furylhydroxymethylketone(17678-19-2)

Safety Data

• Hazardous Substances Data: 17678-19-2(Hazardous Substances Data)

Usage

Description

2-Furylhydroxymethylketone is an organic compound that serves as a versatile reagent in the synthesis of various chemical compounds. It is characterized by its unique chemical structure, which allows it to participate in a range of reactions and contribute to the formation of different products.

Uses

Used in Chemical Synthesis:
2-Furylhydroxymethylketone is used as a reagent for the preparation of 3-iodocoumarins, which are important compounds in the field of chemical research and development. Its ability to participate in chemical reactions makes it a valuable component in the synthesis process.
Used in Dye Industry:
2-Furylhydroxymethylketone is also used in the preparation of quinoxalines, which are generally utilized in the dye industry. These compounds are known for their ability to impart color to various materials, making them essential in the production of a wide range of dyes.
Used in Pharmaceutical Industry:
In addition to its applications in the dye industry, 2-Furylhydroxymethylketone is also used in the pharmaceutical sector. Its role in the synthesis of quinoxalines, which have potential applications in drug development, highlights its importance in this field. The compound's versatility and reactivity make it a valuable asset in the creation of new pharmaceutical products.

InChI:InChI=1/C6H6O3/c7-4-5(8)6-2-1-3-9-6/h1-3,7H,4H2

Upstream product

• 528-50-7 cellobiose 
• 19859-79-1 [2-(furan-2-yl)-2-oxoethyl] acetate 
• 111886-29-4 tert-butyldimethyl((1-(furan-2-yl)vinyl)oxy)silane 
• 691371-32-1 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(2-furanyl)ethanone 
• 141-46-8 Glycolaldehyde 
• 1442748-89-1 C₈H₁₂O₄ 
• 50-99-7 D-glucose 
• 9004-34-6 cellulose 
• 57-50-1 Sucrose 
• 68733-00-6 2,6-di-O-acetyl-1,5-anhydro-4-deoxy-D-glycero-hex-1-en-3-ulose 
• 99648-52-9 (2S)-2',2'-dimethyl-2H-pyran-2-spiro-4'-(1',3'-dioxolan)-3(6H)-one 
• 50-00-0 formaldehyd 
• 552-86-3 furoin 
• 7732-18-5 water 

Downstream Products

• 131496-20-3 (benzoyloxy)methyl 2-furyl ketone 
• 117937-17-4 ethyl (E)-4-(furan-2-yl)-4-oxobut-2-enoate 
• 113452-74-7 (S)-4-(furan-2-yl)oxazolidin-2-one 
• 193528-31-3 (R)-4-(furan-2-yl)oxazolidin-2-one 
• 1352786-48-1 1-(furan-2-yl)-4-phenylbut-3-yne-1,2-dione 
• 705-08-8 glycidyl 2-furancarboxylate 
• 936-75-4 2-chloroethyl furan-2-carboxylate 
• 1438263-68-3 C₁₅H₁₃ClO₅ 
• 1438263-67-2 C₁₂H₉ClO₃ 
• 485355-72-4 C₁₂H₉BrO₃ 

Relevant articles and documents

Direct conversion of cellulose to 1-(furan-2-yl)-2-hydroxyethanone in zinc chloride solution under microwave irradiation

Conversion of cellulose to 1-(furan-2-yl)-2-hydroxyethanone has been demonstrated in concentrated zinc chloride solution under microwave irradiation. Compared with the conventional oil-bath heating mode, microwave irradiation significantly reduced the reaction time and increased the yield of 1-(furan-2-yl)-2-hydroxyethanone. A typical degradation reaction with cellulose produced 1-(furan-2-yl)-2-hydroxyethanone in 12.0% molar yield in ZnCl 2 solution (ZnCl2-H2O ratio = 2.25:1, w/w) with microwave irradiation at 600 W for 5 minutes at 135 °C.

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Identification of 3-hydroxy-6-methyl-2H-pyran-2-one from pyrolysis of phosphoric acid-treated cellulosic materials

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Production of 2-hydroxyacetylfuran from lignocellulosics treated with ionic liquid-water mixtures

Japanese cedar (Cryptomeria japonica) was treated with 12 ionic liquid (IL)-water mixtures at 120 °C for 1 h. Production of 5-hydroxymethylfurfural, furfural and 2-hydroxyacetylfuran (2-HAF) was observed by HPLC and GC-MS. This is the first report to identify 2-HAF from lignocellulosics using ILs. The optimal IL-water mixture was found to be a 90% pyridinium chloride and 10% water w/w solution, although any IL-water mixture that contained pyridinium or imidazolium salts produced all three compounds in varying yields.

A new chemical synthesis of Ascopyrone P from 1,5-anhydro-d-fructose

The naturally occurring antioxidant Ascopyrone P (1,5-anhydro-4-deoxy-d-glycero-hex-1-en-3-ulose, 1) was prepared from the rare sugar 1,5-anhydro-d-fructose (AF, 3) in three steps in an overall yield of 36%. Thus, acetylation of 3 afforded the enolone 3,6-di-O-acetyl-1,5-anhydro-4-deoxy-d-glycero-hex-3-en-2-ulopyranose (4), which could be isomerised to 2,6-di-O-acetyl-1,5-anhydro-4-deoxy-d-glycero-hex-1-ene-3-ulose (6). Deacetylation of 6 under mild conditions gave crystalline Ascopyrone P (1).

Chiral Bidentate Phosphoramidite-Pd Catalyzed Asymmetric Decarboxylative Dipolar Cycloaddition for Multistereogenic Tetrahydrofurans with Cyclic N-Sulfonyl Ketimine Moieties

An asymmetric [3 + 2] cycloaddition of vinyl ethylenecarbonates (VECs) and (E)-3-arylvinyl substituted benzo[d] isothiazole 1,1-dioxides has been developed using the Pd complex of a bidentate phosphoramidite (Me-BIPAM) as the catalyst, providing a wide variety of chiral multistereogenic vinyltetrahydrofurans in good yields with excellent diastereo- and enantioselectivities (up to >20:1 dr, 99% ee).

Enantioselective [3 + 2] Cycloaddition Reaction of Ethynylethylene Carbonates with Malononitrile Enabled by Organo/Metal Cooperative Catalysis

The first catalytic asymmetric decarboxylative [3 + 2] cycloaddition reaction of ethynylethylene carbonates with malononitrile has been developed successfully by an organo/copper cooperative system. This strategy led to a series of optically active polysu