1775-44-6

Basic information

• Product Name: 4-METHYLPENT-2-ENOIC ACID
• Synonyms: 4-METHYLPENT-2-ENOIC ACID
• CAS NO: 1775-44-6
• Molecular Formula: C₆H₁₀O₂
• Molecular Weight: 114.14
• Mol File: 1775-44-6.mol
• Article Data: 25

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-METHYLPENT-2-ENOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLPENT-2-ENOIC ACID(1775-44-6)
• EPA Substance Registry System: 4-METHYLPENT-2-ENOIC ACID(1775-44-6)

Safety Data

• Hazardous Substances Data: 1775-44-6(Hazardous Substances Data)

Usage

General Description

4-Methylpent-2-enoic acid, also known as 4-Methylcrotonic acid, is a chemical compound with the molecular formula C6H10O2. It is a white crystalline solid with a fruity odor and is commonly used as a building block in organic synthesis. It is also used as an intermediate in the production of pharmaceuticals, flavors, and fragrances. 4-METHYLPENT-2-ENOIC ACID has been found to have antimicrobial properties and potential applications in the food and cosmetic industries. Additionally, 4-Methylpent-2-enoic acid is known to be a potential precursor for the synthesis of bioactive compounds for medicinal purposes.

Upstream product

• 141-82-2 malonic acid 
• 78-84-2 isobutyraldehyde 
• 3095-95-2 diethylphosphonoacetic acid 
• 40309-42-0 ethyl 3-hydroxy-4-methylpentanoate 
• 65946-59-0 (trimethylsilyl)ketene bis(trimethylsilyl) acetal 
• 15790-86-0 ethyl-4-methyl-2-(E)-penteneoate 
• 69143-05-1 (E)-4-methyl-pent-2-en-1-ol 
• 20515-15-5 methyl (2E)-4-methylpent-2-enoate 
• 1669-43-8 (E)-4-isopropylbut-3-en-2-one 

Downstream Products

• 1421671-84-2 (3S,4S)-3-[3-(4-methylphenyl)-4-methylpentanoyl]-4-phenyloxazolidin-2-one 
• 1421671-85-3 (+)-(3S)-3-(4-methylphenyl)-4-methylpentanoic acid 
• 1421671-86-4 (+)-(5S)-2-diazo-5-(4-methylphenyl)-6-methylheptan-3-one 
• 170969-86-5 (E)-N-methoxy-N-methyl 4-methyl-pent-2-enamide 
• 144139-22-0 (2R,3S)-5-Methyl-3-(morpholine-4-carbonyl)-2-phenyl-hex-4-enoic acid tert-butyl ester 
• 144139-22-0 (2S,3S)-5-Methyl-3-(morpholine-4-carbonyl)-2-phenyl-hex-4-enoic acid tert-butyl ester 
• 144139-24-2 (2S,3R)-5-Methyl-3-(morpholine-4-carbonyl)-2-phenyl-hex-4-enoic acid methyl ester 
• 144139-24-2 (2S,3S)-5-Methyl-3-(morpholine-4-carbonyl)-2-phenyl-hex-4-enoic acid methyl ester 
• 144139-26-4 (E)-3,3-Dimethyl-6-morpholin-4-yl-6-oxo-2-phenyl-hex-4-enoic acid tert-butyl ester 
• 144139-27-5 (E)-3,3-Dimethyl-6-morpholin-4-yl-6-oxo-2-phenyl-hex-4-enoic acid methyl ester 
• 138895-35-9 (2S,3R)-2-(2-Methyl-propenyl)-3-phenyl-succinic acid 4-tert-butyl ester 1-((1R,2S)-2-phenyl-cyclohexyl) ester 
• 144179-60-2 (2S,3R)-2-(2-Methyl-propenyl)-3-phenyl-succinic acid 4-tert-butyl ester 1-((1R,2S)-2-phenyl-cyclohexyl) ester 
• 138895-31-5 (E) (1'R*,2'S*) phenylcyclohexyl-4-bromo-4-methyl-pent-2-enoate 
• 138895-31-5 (E) (1'R,2'S) phenylcyclohexyl-4-bromo-4-methyl-pent-2-enoate 

Relevant articles and documents

COVALENT RAS INHIBITORS AND USES THEREOF

The disclosure features compounds, or pharmaceutically acceptable salts thereof, alone and in combination with other therapeutic agents, pharmaceutical compositions, and protein conjugates thereof, capable of modulating biological processes including Ras, and their uses in the treatment of cancers.

Chiral integrated catalysts composed of bifunctional thiourea and arylboronic acid: Asymmetric aza-Michael addition of α,β-unsaturated carboxylic acids

The first intermolecular asymmetric Michael addition of nitrogen-nucleophiles to α,β-unsaturated carboxylic acids was achieved through a new type of arylboronic acid equipped with chiral aminothiourea. The use of BnONH2 as a nucleophile gives a range of enantioenriched β-(benzyloxy)amino acid derivatives in good yields and with high enantioselectivity (up to 90% yield, 97% enantiomeric excess (ee)). The obtained products are efficiently converted to optically active β-amino acid and 1,2-diamine derivatives.

Synthetic approaches to the daucane sesquiterpene derivatives employing the intramolecular Buchner cyclisation of α-diazoketones

The use of the intramolecular Buchner cyclisation of an α-diazoketone as an approach to the synthesis of daucane sesquiterpenes is described; in particular the synthesis of the cis-fused analogue of dihydro CAF-603. The key step in the synthesis is the intramolecular Buchner cyclisation, which provides the bicyclo[5.3.0]decane framework with the required stereochemistry at the quaternary centre generated in the cyclisation. A synthetic route enabling access to an asymmetric synthesis is also outlined.