177597-23-8

Basic information

• Product Name: 2-bromo-1-(2-bromoethoxy)-4-nitrobenzene
• Synonyms: 2-bromo-1-(2-bromoethoxy)-4-nitrobenzene
• CAS NO: 177597-23-8
• Molecular Weight: 324.956
• Mol File: 177597-23-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-bromo-1-(2-bromoethoxy)-4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-1-(2-bromoethoxy)-4-nitrobenzene(177597-23-8)
• EPA Substance Registry System: 2-bromo-1-(2-bromoethoxy)-4-nitrobenzene(177597-23-8)

Safety Data

• Hazardous Substances Data: 177597-23-8(Hazardous Substances Data)

Upstream product

• 100-02-7 4-nitro-phenol 
• 5847-59-6 2-bromo-4-nitrophenol 
• 106-93-4 ethylene dibromide 

Downstream Products

• 177597-24-9 1-(2-bromo-4-nitrophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane 
• 177597-25-0 1-(2-bromo-4-aminophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane 

Relevant articles and documents

Expedient Access to 2-Benzazepines by Palladium-Catalyzed C?H Activation: Identification of a Unique Hsp90 Inhibitor Scaffold

Bioactive 2-benzazepines were accessed in an atom- and step-economical manner through a versatile palladium-catalyzed C?H activation strategy. The C?H arylation required low catalyst loading and a mild base, which was reflected by a broad scope and high functional-group tolerance. The benzotriazolodiazepinones were identified as new heat shock protein 90 (Hsp90) inhibiting lead compounds, with considerable potential for anti-cancer applications.

Synthesis and biological activity of KCB-328 and its analogues: Novel class III antiarrhythmic agents with little reverse frequency dependence

A series of 3,4-dimethoxyphenethylamine derivatives was prepared, and their prolongation effects on effective refractory period of contractile response (ERPc) and action potential duration (APD) in isolated guinea-pig papillary muscles at 1 Hz and 3 Hz were examined. SAR studies led to the identification of KCB-328 (51) which is a novel class III antiarrhythmic agent with little reverse frequency dependence.