1776-28-9

Basic information

• Product Name: 2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(2-hydroxyphenyl)-
• CAS NO: 1776-28-9
• Molecular Formula: C17H16O5
• Molecular Weight: 300.311
• Mol File: 1776-28-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(2-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(2-hydroxyphenyl)-(1776-28-9)
• EPA Substance Registry System: 2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(2-hydroxyphenyl)-(1776-28-9)

Safety Data

• Hazardous Substances Data: 1776-28-9(Hazardous Substances Data)

Upstream product

• 90-02-8 salicylaldehyde 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 5896-17-3 2-(phenylmethoxy)benzaldehyde 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 108-73-6 3,5-dihydroxyphenol 
• 5533-04-0 2-(methoxymethoxy)benzaldehyde 
• 110048-26-5 2'-hydroxy-4',6'-dimethoxy-2-methoxymethoxy-trans-chalcone 

Downstream Products

• 109251-39-0 2-(2-hydroxyphenyl)-5,7-dimethoxychroman-4-one 
• 1386981-10-7 2-(5,7-dimethoxy-4-oxochroman-2-yl)phenyl phenylcarbamate 

Relevant articles and documents

Design, synthesis and biological evaluation of dimethyl cardamonin (DMC) derivatives as P-glycoprotein-mediated multidrug resistance reversal agents

Background: P-glycoprotein (P-gp) has been regarded as an important factor in the multidrug resistance (MDR) of tumor cells within the last decade, which can be solved by inhibiting P-gp to reverse MDR. Thus, it is an effective strategy to develop inhibitor of P-gp. Objective: In this study, the synthesis of a series of derivatives had been carried out by bioisosterism design on the basis of Dimethyl Cardamonin (DMC). Subsequently, we evaluated their reversal activities as potential P-glycoprotein (P-gp)-mediated Multidrug Resistance (MDR) agents. Methods: Dimethyl cardamonin derivatives were synthesized from acetophenones and the corresponding benzaldehydes in the presence of 40% KOH by Claisen-Schmidt reaction. Their cytotoxicity and reversal activities in vitro were assessed with MTT. Moreover, the compound B4 was evaluated by Doxorubicin (DOX) accumulation, Western blot and wound-healing assays deeply. Results and Discussion: The results showed that compounds B2, B4 and B6 had the potency of MDR reversers with little intrinsic cytotoxicity. Meanwhile, these compounds also demonstrated the capability to inhibit MCF-7 and MCF-7/DOX cells migration. Besides, the most compound B4 was selected for further study, which promoted the accumulation of DOX in MCF-7/DOX cells and inhibited the expressionof P-gp at protein levels. Conclusion: The above findings may provide new insights for the research and development of P-gp-mediated MDR reversal agents.

Synthesis and evaluation of novel carbamate-substituted flavanone derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents

This study was designed to synthesize and evaluate flavanone derivatives with phenylcarbamate moiety as potent acetylcholinesterase (AChE) inhibitors and anti-amnestic agents for management of AD. The synthesis of carbamate-substituted flavanone derivativ