1779-48-2 Usage
Description
Phenylphosphinic acid, also known as phenylphosphonous acid, is a white crystalline compound with unique chemical properties. It has been studied for its kinetics of oxidation by metal and non-metal oxidants, showcasing its potential for various applications in different industries.
Uses
1. Antioxidant Applications:
Phenylphosphinic acid is used as an antioxidant, providing protection against oxidative stress and damage in various chemical processes and industrial applications.
2. Intermediate for Metallic-Salt Formation:
Phenylphosphinic acid serves as an intermediate in the formation of metallic salts, which are essential in the production of various chemical compounds and materials.
3. Accelerator for Organic Peroxide Catalysts:
Phenylphosphinic acid is used as an accelerator for organic peroxide catalysts, enhancing the efficiency and speed of chemical reactions in the synthesis of various products.
4. Biochemical Marker in Medical Research:
Used in Medical Research:
Phenylphosphinic acid is used as an intermediate in the synthesis of Coproporphyrin I-15N4, which is a vital component in the production of Coproporphyrin I-15N4 Sodium Bisulfate Salt. Phenylphosphinic acid serves as a biochemical marker for distinguishing familial and sporadic porphyria cutanea tarda, as well as a biomarker of environmental toxicity and susceptibility in autism.
5. Environmental Applications:
Phenylphosphinic acid is used in environmental applications as a biomarker to assess the level of toxicity and susceptibility in various ecosystems, contributing to the understanding and management of environmental health.
Purification Methods
Crystallise it from H2O (solubility is 7.7% at 25o). Also purify it by placing the solid in a flask covered with dry Et2O, and allowed it to stand for 1day with intermittent shaking. Et2O is decanted off and the process repeated. After filtration, excess Et2O is removed in a vacuum. It has also been recrystallised from *C6H6. [Michaelis Justus Liebigs Ann Chem 181 265 1876, Banks & Skoog Anal Chem 29 109 1957, NMR: Van Wazer et al. J Am Chem Soc 78 5715 1956, Beilstein 16 IV 1033.]
Check Digit Verification of cas no
The CAS Registry Mumber 1779-48-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,7 and 9 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1779-48:
(6*1)+(5*7)+(4*7)+(3*9)+(2*4)+(1*8)=112
112 % 10 = 2
So 1779-48-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H7O2P/c7-9(8)6-4-2-1-3-5-6/h1-5,9H,(H,7,8)
1779-48-2Relevant articles and documents
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Sen Gupta
, p. 590 (1970)
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Synthesis and evaluation of phosphorus containing, specific CDK9/CycT1 inhibitors
Németh, Gábor,Greff, Zoltán,Sipos, Anna,Varga, Zoltán,Székely, Rita,Sebestyén, Mónika,Jászay, Zsuzsa,Béni, Szabolcs,Nemes, Zoltán,Pirat, Jean-Luc,Volle, Jean-No?l,Virieux, David,Gyuris, ágnes,Kelemenics, Katalin,áy, éva,Minarovits, Janos,Szathmary, Susan,Kéri, Gy?rgy,Orfi, László
, p. 3939 - 3965 (2014/06/09)
Although there is a significant effort in the design of a selective CDK9/CycT1 inhibitor, no compound has been proven to be a specific inhibitor of this kinase so far. The aim of this research was to develop novel and selective phosphorus containing CDK9/CycT1 inhibitors. Molecules bearing phosphonamidate, phosphonate, and phosphinate moieties were synthesized. Prepared compounds were evaluated in an enzymatic CDK9/CycT1 assay. The most potent molecules were tested in cell-based toxicity and HIV proliferation assays. Selectivity of shortlisted compounds against CDKs and other kinases was tested. The best compound was shown to be a highly specific, ATP-competitive inhibitor of CDK9/CycT1 with antiviral activity.
Revisited synthesis of aryl-H-phosphinates
Volle, Jean-Noel,Filippini, Damien,Midrier, Camille,Sobecki, Michal,Drag, Marcin,Virieux, David,Pirat, Jean-Luc
body text, p. 2490 - 2494 (2011/09/20)
A systematic study of the reaction conditions for the preparation of pure aryl-H-phosphinate esters, originally developed by Sander and optimized by Petnehazy, is reported. The influence of the reaction concentration has been investigated for the formation of phosphonite intermediates via direct addition of triethyl phosphite to the appropriate Grignard reagent. Subsequent hydrolysis of the phosphonites under acidic conditions gives various aryl-H-phosphinates in high yields and purities. Georg Thieme Verlag Stuttgart, New York.
