17797-10-3

Basic information

• Product Name: 1-(4-FLUOROPHENYL)-1-METHYL-ETHYLAMINE
• Synonyms: 1-(4-FLUOROPHENYL)-1-METHYL-ETHYLAMINE;1-(4-Fluorophenyl)-1-methylethylamine 97%;1-(4-Fluorophenyl)-1-methylethylamine97%;2-(4-fluorophenyl)propan-2-amine;alpha,alpha-Dimethyl-4-fluorobenzylamine;1-(4-Fluorophenyl)-1-methylethylamine, 2-(4-Fluorophenyl)propan-2-amine;BenzeneMethanaMine, 4-fluoro-a,a-diMethyl-;1-(4-Fluorophenyl)-1-methylethylamine, alpha,alpha-Dimethyl-4-fluorobenzylamine
• CAS NO: 17797-10-3
• Molecular Formula: C₉H₁₂FN
• Molecular Weight: 153.2
• Product Categories: Aminomethyl's;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 17797-10-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 200.6°C at 760 mmHg
• Flash Point: 84.1°C
• Appearance: Clear colorless/Liquid
• Density: 1.038g/cm³
• Vapor Pressure: 0.321mmHg at 25°C
• Refractive Index: 1.502
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 1-(4-FLUOROPHENYL)-1-METHYL-ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUOROPHENYL)-1-METHYL-ETHYLAMINE(17797-10-3)
• EPA Substance Registry System: 1-(4-FLUOROPHENYL)-1-METHYL-ETHYLAMINE(17797-10-3)

Safety Data

• Hazard Codes: C
• Statements: 34-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 3259
• HazardClass: IRRITANT
• Hazardous Substances Data: 17797-10-3(Hazardous Substances Data)

Usage

Description

1-(4-FLUOROPHENYL)-1-METHYL-ETHYLAMINE is an organic compound that serves as a valuable synthetic intermediate in the pharmaceutical industry. It is characterized by its unique molecular structure, which includes a fluorophenyl group and a methylethylamine moiety. 1-(4-FLUOROPHENYL)-1-METHYL-ETHYLAMINE is known for its potential applications in the development of various pharmaceutical agents.

Uses

1. Used in Pharmaceutical Synthesis:
1-(4-FLUOROPHENYL)-1-METHYL-ETHYLAMINE is used as a synthetic intermediate for the development of potent cannabinoid CB1 receptor agonists. These agonists have potential therapeutic applications in treating various conditions, such as pain, inflammation, and anxiety, by modulating the endocannabinoid system.
2. Used in Pharmaceutical Synthesis (continued):
1-(4-FLUOROPHENYL)-1-METHYL-ETHYLAMINE is also utilized in the synthesis of potent antagonists of NPBWR1 (GPR7). These antagonists may have potential applications in the treatment of various disorders, including cardiovascular diseases, metabolic syndrome, and obesity, by targeting the NPBWR1 receptor.
3. Used in the Chemical Industry:
In addition to its pharmaceutical applications, 1-(4-FLUOROPHENYL)-1-METHYL-ETHYLAMINE may also be used as a building block or intermediate in the chemical industry for the synthesis of other complex organic molecules with diverse applications.

InChI:InChI=1/C9H12FN/c1-9(2,11)7-3-5-8(10)6-4-7/h3-6H,11H2,1-2H3

Upstream product

• 403-39-4 1-fluoro-4-isopropylbenzene 
• 64798-46-5 p-fluoro-α,α-dimethylbenzyl isocyanate 
• 1194-02-1 4-fluorobenzonitrile 
• 917-54-4 methyllithium 
• 1000141-64-9 C₉H₁₀FN₃ 
• 403-33-8 methyl 4-flurobenzoate 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 402-41-5 4-fluorocumyl alcohol 

Downstream Products

• 1000141-67-2 C₁₈H₂₂F₂N₂O₂S 
• 1134633-28-5 E-2-oxo-4-phenyl-but-3-enoic acid [1-(4-fluorophenyl)-1-methyl-ethyl]amide 
• 1217336-99-6 2-(4-fluorophenyl)-5-(3-(2-(4-fluorophenyl)propan-2-ylcarbamoyl)phenyl)-6-(N-(2-hydroxyethyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide 
• 1418283-32-5 N-[2-(4-fluorophenyl)propan-2-yl]-2-(2,4-dichlorophenoxy)propanamide 
• 1327826-18-5 N-(1-methyl-1-(4-fluorophenyl)ethyl)picolinamide 
• 1422208-39-6 C₂₄H₃₃FN₂O₃ 
• 1422207-60-0 C₃₃H₄₂FN₃O₃ 
• 1422208-54-5 C₁₉H₂₅FN₂O*ClH 

Relevant articles and documents

Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agent

The optimization campaign for a nitrofuran antitubercular hit (N-benzyl-5-nitrofuran-2-carboxamide; JSF-3449) led to the design, synthesis, and biological profiling of a family of analogs. These compounds exhibited potent in vitro antitubercular activity (MIC = 0.019–0.20 μM) against the Mycobacterium tuberculosis H37Rv strain and low in vitro cytotoxicity (CC50 = 40–>120 μM) towards Vero cells. Significant improvements in mouse liver microsomal stability and mouse pharmacokinetic profile were realized by introduction of an α α-dimethylbenzyl moiety. Among these compounds, JSF-4088 is highlighted due to its in vitro antitubercular potency (MIC = 0.019 μM) and Vero cell cytotoxicity (CC50 > 120 μM). The findings suggest a rationale for the continued evolution of this promising series of antitubercular small molecules.

CANNABINOID RECEPTOR LIGANDS AND USES THEREOF

Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein.

Heterosubstituted pyridine derivatives as PDE4 inhibitors

The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3′,5′-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE 4). or a pharmaceutically acceptable salt or hydrate thereof. The invention also encompasses pharmaceutical compositions and methods for treatment.