17833-07-7

Basic information

• Product Name: 2-PHENYLIMIDAZO[2,1-B][1,3]BENZOTHIAZOLE
• Synonyms: 2-PHENYLIMIDAZO[2,1-B][1,3]BENZOTHIAZOLE;BUTTPARK 2\01-44;2-PHENYL-BENZO(D)IMIDAZO(2,1-B)THIAZOLE
• CAS NO: 17833-07-7
• Molecular Formula: C₁₅H₁₀N₂S
• Molecular Weight: 250.3183
• Mol File: 17833-07-7.mol
• Article Data: 33

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-PHENYLIMIDAZO[2,1-B][1,3]BENZOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYLIMIDAZO[2,1-B][1,3]BENZOTHIAZOLE(17833-07-7)
• EPA Substance Registry System: 2-PHENYLIMIDAZO[2,1-B][1,3]BENZOTHIAZOLE(17833-07-7)

Safety Data

• Hazardous Substances Data: 17833-07-7(Hazardous Substances Data)

Upstream product

• 136-95-8 2-amino-benzthiazole 
• 70-11-1 α-bromoacetophenone 
• 79889-86-4 2-imino-3-phenacyl-2,3-dihydrobenzothiazole hydrobromide 
• 75-52-5 nitromethane 
• 100-52-7 benzaldehyde 
• 536-74-3 phenylacetylene 
• 100-42-5 styrene 
• 4636-16-2 iodoacetophenone 
• 100-41-4 ethylbenzene 
• 137-07-5 2-amino-benzenethiol 
• 120-75-2 2-Methylbenzothiazole 
• 95-16-9 1,3-Benzothiazole 
• 613-91-2 acetophenone oxime 
• 19433-17-1 acetophenone O-acetyloxime 

Downstream Products

• 17833-10-2 (2-phenyl-benzo[d]imidazo[2,1-b]thiazol-3-yl)-succinic acid 
• 14956-44-6 3-(4-nitro-phenylazo)-2-phenyl-benzo[d]imidazo[2,1-b]thiazole 
• 17833-08-8 diethyl 1-(2-phenylbenzo[d]imidazo[2,1-b]thiazol-3-yl)hydrazine-1,2-dicarboxylate 
• 17833-15-7 2-(4-nitrophenyl)benzo[d]imidazo[2,1-b]thiazole 
• 17833-13-5 3-nitroso-2-phenylbenzo[d]imidazo[2,1-b]thiazole 
• 17833-14-6 3-nitro-2-(4-nitro-phenyl)-benzo[d]imidazo[2,1-b]thiazole 
• 121060-34-2 3-Dimethylaminomethyl-2-phenylimidazo<2,1-b>benzothiazole 
• 127204-71-1 2-phenylimidazo[2,1-b][1,3]benzothiazole-3-carbaldehyde 
• 66085-32-3 2,3-dibenzoylpyrrolo<2,1-b>benzothiazole 
• 127204-59-5 3-(2-Phenyl-benzo[d]imidazo[2,1-b]thiazol-3-yl)-propionic acid 
• 121060-42-2 3-Cyanomethyl-2-phenylimidazo<2,1-b>benzothiazole 
• 121060-38-6 3-Trimethylaminomethyl-2-phenylimidazo<2,1-b>benzothiazole iodide 
• 121060-47-7 2-Phenylimidazo<2,1-b>benzothiazole-3-acetic acid 
• 81292-42-4 1,3-diphenylthieno<3',4':3,4>pyrrolo<2,1-b>benzothiazole 

Relevant articles and documents

Molecular interaction of novel benzothiazolyl triazolium analogues with calf thymus DNA and HSA-their biological investigation as potent antimicrobial agents

The binding behaviour between calf thymus DNA and synthesized benzothiazolyl triazolium derivatives as potent antimicrobial agents was explored by means of spectroscopic applications together with molecular docking study at the sub-domain IIA, binding sit

A convenient [hydroxy(tosyloxy)iodo]benzene-mediated one-pot synthesis of 2-arylimidazo[2,1-b[benzothiazoles

Several 2-arylimidazo[2,1-b]benzothiazoles (4) have been conveniently synthesized in one-pot reactions via α-tosyloxylation of enolizable ketones (1) using [hydroxy(tosyloxy)iodo]benzene 2 in acetonitrile, followed by treatment with 2-amino-6-(substituted

FeCl3/ZnI2-catalyzed synthesis of benzo[D]imidazo[2,1-b]thiazole through aerobic oxidative cyclization between 2-aminobenzothiazole and ketone

The FeCl3/ZnI2-catalyzed aerobic oxidative cyclization between 2-aminobenzothiazole and ketone/chalcone for the synthesis of benzo[d]imidazo[2,1-b]thiazole is described. A variety of fused benzoimidazothiazole derivatives are obtained by this protocol.

Metal-free oxidative decarbonylative halogenation of fused imidazoles

An efficient strategy has been developed for the deformylative halogenation of carbaldehyde imidazo-fused heterocycles in the presence of TBHP controlled by temperature. A convenient and sequential functionalization (C8 to C3) portrays the synthetic utility of the current method.N-Heterocycle benzamide products were also observedviathe ring opening of imidazopyridines through the cleavage of C-C bond at high temperatures. Features of this method include temperature-controlled excellent regioselectivity, mild conditions and functional group tolerance.

Design, synthesis and anticancer activity of sulfenylated imidazo-fused heterocycles

We report herein, the design, synthesis and study of anticancer properties of sulfenylated 2-phenylimidazo[1,2-a]pyridines and their analogues. A set of twenty sulfenylated imidazo[1, 2-a]pyridine derivatives were synthesized. Whereby elusive amendments to the imidazo[1,2-a]pyridine motif confer dramatic changes in functional affinity of a novel action to modulate anticancer activity in seven different human cancer cell lines i.e.: MDA MB 231 (breast), HepG2 (liver), Hela (cervical), A549 (lung), U87MG (glioblastoma), SKMEL-28 (skin melanoma) and DU-145 (prostate) by employing MTT assay. Among the series, compounds 4e (naphthalene), 4f (styrene) and 4h (thiomethyl) showed potent activity towards human liver cancer cells HepG2. Cell cycle analysis results revealed that these compounds arrested the cell cycle at G2/M phase and induced apoptosis in human liver cancer cells HepG2. It was further confirmed by Hoechst staining, Measurement of mitochondrial membrane potential (ΔΨm) and Annexin V-FITC assay.