178625-02-0Relevant articles and documents
Design, Synthesis, and Evaluation of Chalcone Derivatives as Multifunctional Agents against Alzheimer's Disease
Wang, Xiao-Qin,Zhou, Lu-Yi,Tan, Ren-Xian,Liang, Guo-Peng,Fang, Si-Xian,Li, Wei,Xie, Mei,Wen, Yu-Hao,Wu, Jia-Qiang,Chen, Yi-Ping
, (2021/10/19)
Fifteen chalcone derivatives 3a–3o were synthesized, and evaluated as multifunctional agents against Alzheimer's disease. In vitro studies revealed that these compounds inhibited self-induced Aβ1-42 aggregation effectively ranged from 45.9–94.5