17896-21-8Relevant articles and documents
Preparation Method for Homocystein Thiolactone or Selenolactone
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Paragraph 0037-0040, (2021/09/14)
The present invention provides an expensive reagent such as homocysteine thiolactone or selenolactone as the main intermediate of erdosteine, or an expensive reagent such as HI. More specifically, A) a homoserine lactone or N - protected homoserine is reacted with a thiocarboxylic acid metal salt or selenocarboxylic acid metal salt (RCOXM, X=S or Se). B) Step A) of producing homocysteine thiolactone or homocysteine sonoactone by deprotection of N - protected homocysteine thiolactone or N - protected homocysteine seleactone. The present invention relates to a method for producing homocysteine thiactone or homocysteine senolactone or a salt thereof by the following reaction scheme. [Reaction Scheme] Then, this time. X Is S or Se, R and R ' are independently alkyl or aryl which is C1 - C6, and M is Na or K.
Two tandem multicomponent reactions for the synthesis of sequence-defined polymers
Yang, Lu,Zhang, Ze,Cheng, Bofei,You, Yezi,Wu, Decheng,Hong, Chunyan
, p. 1734 - 1740 (2015/11/02)
Multicomponent polymerizations have become powerful tools for the construction of sequence-defined polymers. Although the Passerini multicomponent reaction has been widely used in the synthesis of sequence-defined polymers, the tandem usage of the Passerini multicomponent reaction and other multicomponent reactions in one-pot for the synthesis of sequence-defined polymers has not been developed until now. In this contribution, we report the tandem usage of the Passerini three-component reaction and the three-component amine-thiol-ene conjugation reaction in one pot for the synthesis of sequence-defined polymers. The Passerini reaction between methacrylic acid, adipaldehyde, and 2-isocyanobutanoate was carried out, affording a new molecule containing two alkene units. Subsequently, an amine and a thiolactone were added to the reaction system, whereupon the three-component amine-thiol-ene conjugating reaction occurred to yield a sequence-defined polymer. This method offers more rapid access to sequence-defined polymers with high molecular diversity and complexity.
Synthesis of sequence-ordered polymers via sequential addition of monomers in one pot
Yan, Jun-Jie,Wang, Di,Wu, De-Cheng,You, Ye-Zi
supporting information, p. 6057 - 6059 (2013/07/27)
Sequence-ordered polymers can be simply prepared in one pot via sequential monomer addition.