179174-79-9Relevant articles and documents
Synthesis of a NO-releasing prodrug of rofecoxib
Engelhardt, F. Conrad,Shi, Yao-Jun,Cowden, Cameron J.,Conlon, David A.,Pipik, Brenda,Zhou, George,McNamara, James M.,Dolling, Ulf-H.
, p. 480 - 491 (2007/10/03)
A newly developed synthesis of a NO-releasing prodrug of rofecoxib is described. The highly productive process consists of five chemical steps and produces prodrug 1 in an overall 64% yield from commercially available 3-phenyl-2-propyn-1-ol (4). The synth
Process for making nitric oxide releasing prodrugs of diaryl-2-(5H)-furanones as cyclooxygenase-2 inhibitors
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Page/Page column 6-8, (2010/02/13)
The invention encompasses a novel process for making compounds of Formula I which are prodrugs of cyclooxygenase-2 selective inhibitors that convert in vivo to diaryl-2-(5H)-furanones and also liberate nitric oxide in vivo. As such, the compounds made by
Stilbene derivatives useful as cyclooxygenase-2 inhibitors
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, (2008/06/13)
The invention encompasses novel compounds of Formula Iuseful in the treatment of cyclooxygenase-2 mediated diseases. STR1 The invention also encompasses certain pharmaceuticalcompositions and methods for treatment of cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula I.