1799612-11-5

Basic information

• Product Name: 1-(2-(2-chloro-3-methyl-4-(4,4,5,5-tetramethyl
• Synonyms: 1-(2-(2-chloro-3-methyl-4-(4,4,5,5-tetramethyl;1-(2-(2-chloro-3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethyl)-4-methylpiperazine
• CAS NO: 1799612-11-5
• Molecular Formula: C20H32BClN2O3
• Molecular Weight: 394.74368
• EINECS: -0
• Mol File: 1799612-11-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 500.1±50.0 °C(Predicted)
• Appearance: /
• Density: 1.14±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 7.57±0.10(Predicted)
• CAS DataBase Reference: 1-(2-(2-chloro-3-methyl-4-(4,4,5,5-tetramethyl(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-(2-chloro-3-methyl-4-(4,4,5,5-tetramethyl(1799612-11-5)
• EPA Substance Registry System: 1-(2-(2-chloro-3-methyl-4-(4,4,5,5-tetramethyl(1799612-11-5)

Safety Data

• Hazardous Substances Data: 1799612-11-5(Hazardous Substances Data)

Usage

General Description

1-(2-(2-chloro-3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)phenyl)ethyl)-2,2,4,4-tetramethyl-1,3,2-dioxaborolane is a complex chemical compound that is used in various applications such as organic synthesis and pharmaceutical research. It is composed of several functional groups including chloro, methyl, and phenyl groups, as well as boron-containing dioxaborolane moieties. 1-(2-(2-chloro-3-methyl-4-(4,4,5,5-tetramethyl has potential uses as a building block for the synthesis of more complex organic molecules, and its unique structure may confer interesting properties for use in a variety of research and industrial applications. The presence of the boron-containing dioxaborolane groups may contribute to its reactivity and potential for use in catalysis or as a ligand for metal complexes. Overall, this chemical offers potential for diverse applications within the field of organic chemistry and materials science.

Upstream product

• 608-26-4 2-chloro-m-cresol 
• 73183-34-3 bis(pinacol)diborane 
• 97329-43-6 1-bromo-2-chloro-3-methyl-benzene 
• 61676-62-8 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 5464-12-0 2-(4-methylpiperazinyl)ethanol 
• 3964-56-5 4-bromo-2-chlorophenol 
• 1799612-08-0 4-bromo-2-chloro-3-methylphenol 

Relevant articles and documents

MCL1 INHIBITORS AND USES THEREOF

The present disclosure provides compounds, such as compounds of Formula I, and compositions that are MCL1 inhibitors.

Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor

Myeloid cell leukemia 1 (Mcl-1) has emerged as an attractive target for cancer therapy. It is an antiapoptotic member of the Bcl-2 family of proteins, whose upregulation in human cancers is associated with high tumor grade, poor survival, and resistance to chemotherapy. Here we report the discovery of our clinical candidate S64315, a selective small molecule inhibitor of Mcl-1. Starting from a fragment derived lead compound, we have conducted structure guided optimization that has led to a significant (3 log) improvement of target affinity as well as cellular potency. The presence of hindered rotation along a biaryl axis has conferred high selectivity to the compounds against other members of the Bcl-2 family. During optimization, we have also established predictive PD markers of Mcl-1 inhibition and achieved both efficient in vitro cell killing and tumor regression in Mcl-1 dependent cancer models. The preclinical candidate has drug-like properties that have enabled its development and entry into clinical trials.

Method for preparing multi-target small-molecule compounds S63845

The invention discloses a method for preparing multi-target small-molecule compounds S63845, and relates to the technical field of chemical synthesis. The method has the advantages that routes for synthesizing the multi-target small-molecule compounds S63