180850-14-0

Basic information

• Product Name: 3-(4-tert-butylphenyl)-2-methylprop-2-enal
• Synonyms: 3-(4-tert-butylphenyl)-2-methylprop-2-enal
• CAS NO: 180850-14-0
• Molecular Weight: 202.296
• Mol File: 180850-14-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(4-tert-butylphenyl)-2-methylprop-2-enal(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-tert-butylphenyl)-2-methylprop-2-enal(180850-14-0)
• EPA Substance Registry System: 3-(4-tert-butylphenyl)-2-methylprop-2-enal(180850-14-0)

Safety Data

• Hazardous Substances Data: 180850-14-0(Hazardous Substances Data)

Upstream product

• 939-97-9 4-tert-Butylbenzaldehyde 
• 123-38-6 propionaldehyde 

Downstream Products

• 213819-66-0 (2E,4E)-1-(2-Benzyloxy-6-hydroxy-phenyl)-5-(4-tert-butyl-phenyl)-4-methyl-penta-2,4-dien-1-one 
• 80-54-6 p-tert-butyl-α-methylhydrocinnamic aldehyde 
• 75166-31-3 (R)-(-)-3-(4-tert-Butylphenyl)-2-methylpropanal 
• 117721-78-5 (E)-3-(4-(tert-butyl)phenyl)-2-methylprop-2-en-1-ol 
• 80-54-6 lilial 
• 79253-37-5 (S)-3-(4-(tert-butyl)phenyl)-2-methylpropan-1-ol 

Relevant articles and documents

Complex Polyheterocycles and the Stereochemical Reassignment of Pileamartine A via Aza-Heck Triggered Aryl C-H Functionalization Cascades

Structurally complex benzo- and spiro-fused N-polyheterocycles can be accessed via intramolecular Pd(0)-catalyzed alkene 1,2-aminoarylation reactions. The method uses N-(pentafluorobenzoyloxy)carbamates as the initiating motif, and this allows aza-Heck-type alkene amino-palladation in advance of C-H palladation of the aromatic component. The chemistry is showcased in the first total synthesis of the complex alkaloid (+)-pileamartine A, which has resulted in the reassignment of its absolute stereochemistry.

Manufacturing of α,β-unsaturated aldehydes and ketones

The preparation of α,β-unsaturated aldehydes and ketones I is carried out by acid hydrolysis of cyclic α,β-unsaturated acetals II STR1 in the presence of saturated aldehydes.