181119-68-6

Basic information

• Product Name: 4-(2-Butoxycarbonylmethoxy-ethyl)-piperazine-1-carboxylic acid benzyl ester
• Synonyms: 4-(2-Butoxycarbonylmethoxy-ethyl)-piperazine-1-carboxylic acid benzyl ester
• CAS NO: 181119-68-6
• Molecular Weight: 378.469
• Mol File: 181119-68-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-Butoxycarbonylmethoxy-ethyl)-piperazine-1-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Butoxycarbonylmethoxy-ethyl)-piperazine-1-carboxylic acid benzyl ester(181119-68-6)
• EPA Substance Registry System: 4-(2-Butoxycarbonylmethoxy-ethyl)-piperazine-1-carboxylic acid benzyl ester(181119-68-6)

Safety Data

• Hazardous Substances Data: 181119-68-6(Hazardous Substances Data)

Upstream product

• 31166-44-6 phenylmethyl 1-piperazinecarboxylate 
• 68448-72-6 2-Chlor-aethoxyesssigsaeure-butylester 

Downstream Products

• 130018-87-0 (+)-Cetirizine dihydrochloride 
• 181119-59-5 (2-{4-[(S)-(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-ethoxy)-acetic acid butyl ester 

Relevant articles and documents

Catalytic enantioselective synthesis of the second generation histamine antagonist cetirizine hydrochloride

The first enantioselective synthesis of cetirizine hydrochloride (1) has been developed using the highly stereospecific chiral oxazaborolidine (CBS) reduction of 4-[η6-chromium tricarbonylbenzoyl]chlorobenzene to establish the benzhydryl stereocenter. The chromium tricarbonyl unit also served as stereocontroller to allow the stereospecific displacement of hydroxyl by amino at the benzylic stereocenter, as outlined in Scheme 1.