181713-52-0Relevant articles and documents
13-Asymmetric induction in the aldol reactions of α-methylene-β-alkoxy aldehydes
Paterson, Ian,Bower, Shelley,Tillyer, Richard D.
, p. 4393 - 4396 (1993)
The aldol reactions of the α-methylene-β-alkoxy aldehydes 3 and 6 were examined for a range of Ti (IV), Sn(II), and B enolates. The sense and level of 1,3-asymmetric induction (up to 95% ds) varies with the enolate structure and the β-hydroxyl protecting
1,4-Asymmetric induction in the Nozaki-Hiyama reaction
Maguire, Robert J.,Mulzer, Johann,Bats, Jan W.
, p. 5487 - 5490 (2007/10/03)
A series of allyl bromides 3a-c bearing a stereogenic carbon substituent at C-2 are synthesized in four steps from methyl acrylate. These are found to react with aldehydes, mediated by chromium(II) chloride, to furnish syn-4-alkoxyalkan-1-ols 4 in good to