18186-43-1

Basic information

• Product Name: Serotonin β-D-Glucuronide
• Synonyms: Serotonin β-D-Glucuronide;3-(2-AMinoethyl)-1H-indol-5-yl β-D-Glucopyranosiduronic acid;5-HydroxytryptaMine Glucuronide;5-HydroxytryptaMine O-Glucuronide
• CAS NO: 18186-43-1
• Molecular Formula: C16H19N2O7
• Molecular Weight: 351.33126
• Product Categories: Aromatics;Glucuronides;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 18186-43-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
• CAS DataBase Reference: Serotonin β-D-Glucuronide(CAS DataBase Reference)
• NIST Chemistry Reference: Serotonin β-D-Glucuronide(18186-43-1)
• EPA Substance Registry System: Serotonin β-D-Glucuronide(18186-43-1)

Safety Data

• Hazardous Substances Data: 18186-43-1(Hazardous Substances Data)

Usage

Description

Serotonin β-D-Glucuronide is a metabolite of 5-Hydroxytryptamine, commonly known as Serotonin. It is a pale orange solid and plays a significant role in various physiological processes within the body.

Uses

1. Used in Pharmaceutical Industry:
Serotonin β-D-Glucuronide is used as a research compound for understanding the metabolism and functions of Serotonin, which is crucial in the regulation of mood, appetite, and other physiological processes.
2. Used in Diagnostic Applications:
Serotonin β-D-Glucuronide is used as a diagnostic marker to monitor the levels of Serotonin in the body, which can be indicative of certain medical conditions or disorders related to Serotonin imbalance.
3. Used in Neurochemical Research:
Serotonin β-D-Glucuronide is used as a research tool in neurochemical studies to investigate the role of Serotonin in the central nervous system and its involvement in various neurological and psychiatric disorders.
4. Used in Drug Development:
Serotonin β-D-Glucuronide can be used in the development of new drugs targeting the Serotonin system, potentially leading to novel treatments for conditions such as depression, anxiety, and other mood disorders.
5. Used in Analytical Chemistry:
Serotonin β-D-Glucuronide can be employed as a reference compound in the development and validation of analytical methods for the detection and quantification of Serotonin and its metabolites in biological samples.

Upstream product

• 50-67-9 3-(2-aminoethyl)-1H-indol-5-ol 
• 63700-19-6 uridine-5'-diphospho-α-D-glucuronic acid trisodium salt 

Relevant articles and documents

Species and tissue differences in serotonin glucuronidation

1. Serotonin is a UGT1A6 substrate that is mainly found in the extrahepatic tissues where some UGT1As are expressed. The aim of the present study was to characterize serotonin glucuronidation in various tissues of humans and rodents.2. Serotonin glucuronidation in the human liver and kidney fitted to the Michaelis-Menten model, and the Km values were similar to that of recombinant UGT1A6. However, serotonin glucuronidation in the human intestine fitted to the Hill equation, indicating that it is likely catalyzed not only by UGT1A6, but also by another UGT1A isoform. Serotonin glucuronidation in the rat liver, intestine and kidney fitted well to the Michaelis-Menten model and exhibited monophasic kinetics in the kidney, but biphasic kinetics in the liver and intestine. Furthermore, serotonin glucuronidation in the rat brain fitted best to the Hill equation. Serotonin glucuronidation in the mouse tissues fitted to the Michaelis-Menten model and exhibited monophasic kinetics in the liver and intestine microsomes, but biphasic kinetics in the kidney and brain microsomes.3. In conclusion, we clarified that tissue and species differences exist in serotonin glucuronidation. It is necessary to take these potential differences into account when considering the pharmacodynamics and pharmacokinetics of serotonin.