183067-65-4Relevant articles and documents
Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic α-amylase
Tysoe, Christina R.,Caner, Sami,Calvert, Matthew B.,Win-Mason, Anna,Brayer, Gary D.,Withers, Stephen G.
, p. 11073 - 11077 (2019)
Simplified analogues of the potent human amylase inhibitor montbretin A were synthesised and shown to bind tightly, KI = 60 and 70 nM, with improved specificity over medically relevant glycosidases, making them promising candidates for controlling blood glucose. Crystallographic analysis confirmed similar binding modes and identified new active site interactions.
Synthesis, characterization and antioxidant activity of quercetin derivatives
Sun, Lei,Lu, Bo,Liu, Yandan,Wang, Qian,Li, Gao,Zhao, Longxuan,Zhao, Chunhui
, p. 2944 - 2953 (2021/08/25)
A series of quercetin derivatives were synthesized via Williamson etherification, Steglich esterification or Koenigs–Knorr glycosylation reaction at 3 and 7 position hydroxyl groups selectively. The structures of the synthesized compounds were characteriz
Regiospecific synthesis of three quercetin O-β-glucosides of N-acetylglucosamine
Cao, Zhiling,Chen, Jing,Zhu, Dandan,Yang, Zongnan,Teng, Wenqi,Liu, Gaofeng,Liu, Bing,Tao, Chuanzhou
, p. 189 - 193 (2018/05/26)
The regiospecific synthesis of three quercetin O-β-glucosides of N-acetylglucosamine has been achieved in good yield. Selective di- and tri-O-benzylation of quercetin followed by O-glycosylation with 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-d-glucopyranosyl chloride under phase-transfer catalysis conditions yielded, after deacetylation and debenzylation, 3-, 3′- and 4′-glycosylated quercetin.