1835-16-1

Basic information

• Product Name: 1-Propanone, 2-bromo-1-[3-methoxy-4-(phenylmethoxy)phenyl]-
• CAS NO: 1835-16-1
• Molecular Formula: C17H17BrO3
• Molecular Weight: 349.224
• Mol File: 1835-16-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 2-bromo-1-[3-methoxy-4-(phenylmethoxy)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 2-bromo-1-[3-methoxy-4-(phenylmethoxy)phenyl]-(1835-16-1)
• EPA Substance Registry System: 1-Propanone, 2-bromo-1-[3-methoxy-4-(phenylmethoxy)phenyl]-(1835-16-1)

Safety Data

• Hazardous Substances Data: 1835-16-1(Hazardous Substances Data)

Usage

Class

Ketones with a bromo-substituted aromatic ring

Common uses

Organic synthesis, pharmaceutical research

Functional groups

Bromo group, methoxy group on the phenyl ring, propanone functional group

Potential applications

Development of new drugs, design and synthesis of organic compounds for medical and industrial use

Implications

Study and research of chemical reactions and mechanisms in organic chemistry

Upstream product

• 119384-94-0 1-(4-benzyloxy-3-methoxyphenyl)-2-bromo-1-propanol 
• 1835-15-0 1-(4-benzyloxy-3-methoxyphenyl)propan-1-one 
• 92666-21-2 (E)-2-methoxy-1-(phenylmethoxy)-4-(prop-1-en-1-yl)benzene 
• 100-39-0 benzyl bromide 
• 121-33-5 vanillin 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 5438-66-4 1-(4-Benzyloxy-3-methoxy-phenyl)-propan-1-ol 

Downstream Products

• 61324-71-8 1,4-bis(4-benzyloxy-3-methoxyphenyl)-2,3-dimethylbutane-1,4-dione 
• 10035-27-5 4,4'-(3,4-dimethylfuran-2,5-diyl)bis(2-methoxyphenol) 
• 61324-72-9 2,5-bis(4-benzyloxy-3-methoxyphenyl)-3,4-dimethylfuran 
• 1835-10-5 (1RS,2SR)-1-(3,4-dimethoxy-phenyl)-2-(2-methoxy-phenoxy)-propan-1-ol 
• 1774-10-3 (1RS,2SR)-1-(4-hydroxy-3-methoxy-phenyl)-2-(2-methoxy-phenoxy)-propan-1-ol 
• 119385-00-1 8-Benzyloxy-7-[(1R,2S)-2-(4-benzyloxy-3-methoxy-phenyl)-2-hydroxy-1-methyl-ethoxy]-6-methoxy-chromen-2-one 
• 119385-00-1 8-Benzyloxy-7-[(1R,2R)-2-(4-benzyloxy-3-methoxy-phenyl)-2-hydroxy-1-methyl-ethoxy]-6-methoxy-chromen-2-one 
• 119384-96-2 8-[(1R,2S)-2-(4-Benzyloxy-3-methoxy-phenyl)-2-hydroxy-1-methyl-ethoxy]-6-methoxy-7-methoxymethoxy-chromen-2-one 
• 119384-96-2 8-[(1R,2R)-2-(4-Benzyloxy-3-methoxy-phenyl)-2-hydroxy-1-methyl-ethoxy]-6-methoxy-7-methoxymethoxy-chromen-2-one 
• 51149-38-3 4-[2-(4-Benzyloxy-3-methoxy-phenyl)-1-methyl-2-oxo-ethoxy]-3,5-dimethoxy-benzaldehyde 
• 7203-54-5 1-(3-Methoxy-4-benzyloxy-phenyl)-2-(2-methoxy-phenoxy)-1-propanon 

Relevant articles and documents

Structure-activity relationships of talaumidin derivatives: Their neurite-outgrowth promotion in vitro and optic nerve regeneration in vivo

(–)-Talaumidin (1), a 2,5-biaryl-3,4-dimethyltetrahydrofuran lignan, shows potent neurotrophic activities such as neurite-outgrowth promotion and neuroprotection. Previously, we found that (–)-(1S,2R,3S,4R)-stereoisomer 2 exhibited more significant activity than did the natural product talaumidin (1). However, the preparation of optically active (–)-2 requires a complicated synthetic route. To explore new neurotrophic compounds that can be obtained on a large scale, we established a short step synthetic route for talaumidin derivatives and synthesized fourteen analogues based on the structure of (–)-2. First, we synthesized a racemic compound of (–)-2 (2a) and assessed its neurotrophic activity. We found that the neurotrophic property of racemic 2a is similar in activity to that of (–)-2. Using the same synthetic methodology, several talaumidin derivatives were synthesized to optimize the oxy-functionality on aromatic rings. As a result, bis(methylenedioxybenzene) derivative 2b possessed the highest neurotrophic activity. Furthermore, examination of the structure-activity relationships of 2b revealed that the 2,5-diphenyl-tetrahydrofuran structure was an essential structure and that two methyl groups on THF ring could enhance neurotrophic activity. In addition, compounds 2a and 2b were found to induce mouse optic nerve regeneration in vivo.

PHENYLIMIDAZOLE COMPOUNDS

[Object] To provide a pharmaceutical product (chemotherapeutic agent) effective in the prevention and treatment of hyperlipidemia, obesity, etc. [Solving Means] A phenylimidazole compound represented by the following General Formula (1): wherein, R1

Neuroprotective 3-(piperidinyl-1)-chroman-4,7-diol and 1-(4-hydroxyphenyl)-2-(piperidinyl-1)-alkanol derivatives

PCT No. PCT/IB95/00380 Sec. 371 Date Feb. 13, 1996 Sec. 102(e) Date Feb. 13, 1996 PCT Filed May 18, 1995 PCT Pub. No. WO96/06081 PCT Pub. Date Feb. 29, 1996This invention relates to compounds of formula (I), or pharmaceutically acceptable acid addition salts thereof, wherein: (a) R2 and R5 are taken separately and R1, R2, R3 and R4 are each independently hydrogen, (C1-C6) alkyl, halo, CF3, OH or OR7 and R5 is methyl or ethyl; or (b) R2 and R5 are taken together, forming a chroman-4-ol ring, and R1, R3 and R4 are each independently hydrogen, (C1-C6) alkyl, halo, CF3, OH or OR7; and R6 is a substituted piperidinyl, pyrrolidinyl or 8-azabicyclo(3.2.1)octanyl derivative; provided that (a) when R2 and R5 are taken separately, at least one of R1, R2, R3 and R4 is not hydrogen; and (b) when R2 and R5 are taken together, at least one of R1, R3 and R4 is not hydrogen; pharmaceutical compositions thereof; and methods of treating mammals suffering from stroke, spinal cord trauma, traumatic brain injury, multiinfarct dementia, CNS degenerative diseases such as Alzheimer's disease, senile dementia of the Alzheimer's type, Huntington's disease, Parkinson's disease, epilepsy, amyotrophic lateral sclerosis, pain, AIDS dementia, psychotic conditions, drug addictions, migraine, hypoglycemia, anxiolytic conditions, urinary incontinence and an ischemic event arising from CNS surgery, open heart surgery or any procedure during which the function of the cardiovascular system is compromised with a compound of formula (I) hereinabove or a pharmaceutically acceptable salt thereof.