183550-80-3

Basic information

• Product Name: 8H-Pyrano[3,4-b]pyridine-6-carboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-(4-methylphenyl)-8-oxo-
• CAS NO: 183550-80-3
• Molecular Formula: C25H16F6N2O3
• Molecular Weight: 506.404
• Mol File: 183550-80-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 8H-Pyrano[3,4-b]pyridine-6-carboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-(4-methylphenyl)-8-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 8H-Pyrano[3,4-b]pyridine-6-carboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-(4-methylphenyl)-8-oxo-(183550-80-3)
• EPA Substance Registry System: 8H-Pyrano[3,4-b]pyridine-6-carboxamide, N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-(4-methylphenyl)-8-oxo-(183550-80-3)

Safety Data

• Hazardous Substances Data: 183550-80-3(Hazardous Substances Data)

Upstream product

• 183550-77-8 diethyl 5,6-dihydro-5-hydroxy-5-(4-methylphenyl)-8-oxo-8H-pyrano[3,4-b]pyridine-6,6-dicarboxylate 
• 183550-78-9 5-(4-methylphenyl)-8-oxo-8H-pyrano[3,4-b]pyridine-6-carboxylic acid 
• 508210-05-7 3-p-toluoyl-pyridine-2-carbonyl chloride 
• 116060-91-4 3-(4-methylbenzoyl)-2-pyridine carboxylic acid 
• 85068-29-7 3,5-bis-trifluoromethylbenzylamine 
• 508210-17-1 8-Oxo-5-p-tolyl-8H-pyrano[3,4-b]pyridine-6-carbonyl chloride 

Downstream Products

• 183550-82-5 N-[3,5-bis(trifluoromethyl)benzyl]-7,8-dihydro-7-(4-hydroxybutyl)-5-(4-methylphenyl)-8-oxo-1,7-naphthyridine-6-carboxamide 
• 183550-85-8 N-[3,5-bis(trifluoromethyl)benzyl]-7,8-dihydro-7-(5-hydroxypentyl)-5-(4-methylphenyl)-8-oxo-1,7-naphthyridine-6-carboxamide 
• 244106-99-8 (+/-)-N-[3,5-bis(trifluoromethyl)benzyl]-7,8-dihydro-7-[4-hydroxy-3-(1-methylethyl)butyl)-5-(4-methylphenyl)-8-oxo-6-pyrido[3,4-b]pyridine carboxamide 
• 183550-96-1 (S)-N-[3,5-bis(trifluoromethyl)benzyl]-7,8-dihydro-7-(3-hydroxy-2-methylpropyl)-5-(4-methylphenyl)-8-oxo-1,7-naphthyridine-6-carboxamide 
• 183549-95-3 (aR,9S)-7-[3,5-bis(trifluoromethyl)benzyl]-8,9,10,11-tetrahydro-9-methyl-5-(4-methylphenyl)-7H-[1,4]diazocino[2,1-g][1,7]naphthyridine-6,13-dione 
• 244107-37-7 N-[3,5-bis(trifluoromethyl)benzyl]-7,8-dihydro-7-(2-methanesulfonyloxyethyl)-5-(4-methylphenyl)-8-oxo-6-pyrido[3,4-b]pyridine carboxamide 
• 183145-60-0 7-[3,5-Bis(trifluoromethyl)benzyl]-6,7,8,9-tetrahydro-5-(4-methylphenyl)-6,11-dioxo-11H-pyrazino[2,1-g][1,7]naphthyridine 
• 183551-02-2 (R)-N-[3,5-bis(trifluoromethyl)benzyl]-7,8-dihydro-7-(4-hydroxy-3-methylbutyl)-5-(4-methylphenyl)-8-oxo-1,7-naphthyridine-6-carboxamide 
• 183551-04-4 (S)-N-[3,5-bis(trifluoromethyl)benzyl]-7,8-dihydro-7-(4-hydroxy-3-methylbutyl)-5-(4-methylphenyl)-8-oxo-1,7-naphthyridine-6-carboxamide 
• 183549-95-3 (aS,9S)-7-[3,5-bis(trifluoromethyl)benzyl]-8,9,10,11-tetrahydro-9-methyl-5-(4-methylphenyl)-7H-[1,4]diazocino[2,1-g][1,7]naphthyridine-6,13-dione 
• 183549-95-3 (aS,9R)-7-[3,5-bis(trifluoromethyl)benzyl]-8,9,10,11-tetrahydro-9-methyl-5-(4-methylphenyl)-7H-[1,4]diazocino[2,1-g][1,7]naphthyridine-6,13-dione 
• 183549-95-3 (aR,9R)-7-[3,5-bis(trifluoromethyl)benzyl]-8,9,10,11-tetrahydro-9-methyl-5-(4-methylphenyl)-7H-[1,4]diazocino[2,1-g][1,7]naphthyridine-6,13-dione 

Relevant articles and documents

DRUGS

The present invention relates to a medicine which comprises a compound (I) of the formula:[wherein the ring M is a heterocylic ring having -N=Ca and Rb are bound to each other to form the ring A, or they are the same or different each representing a hydrogen atom or a substituent on the ring M;the rings A and B each is an optionally substituted homocycle or heterocycle, and at least one of them is an optionally substituted heterocycle;the ring C is an optionally substituted homocycle or heterocycle;the ring Z is an optionally substituted nitrogen-containing heterocycle; andn is an integer of 1 to 6] or a salt thereof in combination with a drug having an emetic action. The compounds (I) or their salts are useful as anti-emetic drugs. Particularly, vomiting caused by drugs having an emetic action can be inhibited by these compounds rapidly and safely at a low dose.

Enantioselective synthesis of an axially chiral 1,7-naphthyridine-6-carboxamide derivative having potent antagonist activity at the NK1 receptor

A new and highly potent NK1 antagonist, (aR,9R)-3 [(aR,9R)-7-[3,5-bis(trifluoromethyl)benzyl]-8,9,10,11-tetrahydro-9-methyl-5-(4- methylphenyl)-7H-[1,4]diazocino[2,1-g][1,7]naphthyridine-6,13-dione], was atropdiastereoselectively synthesized in