184370-59-0Relevant articles and documents
Direct Access to α,β-Unsaturated Ketones via Rh/MgCl2-Mediated Acylation of Vinylsilanes
Chen, Zi-Yan,Deng, Xue-Zu,Song, Yang,Xue, Fei,Yamane, Motoki,Yue, Yan-Ni
, p. 12693 - 12704 (2021/09/28)
We report herein the facile and practical construction of α,β-unsaturated ketones via rhodium-catalyzed direct acylation of vinylsilanes with readily available and abundant carboxylic acids. This protocol features access to a diverse array of synthetically useful functionalities with moderate to excellent yields. More importantly, the late-stage functionalization of pharmaceuticals was also realized with synthetically useful yield.
Stereodivergent Olefination of Enantioenriched Boronic Esters
Armstrong, Roly J.,García-Ruiz, Cristina,Myers, Eddie L.,Aggarwal, Varinder K.
supporting information, p. 786 - 790 (2017/01/14)
A stereodivergent coupling reaction between vinyl halides and boronic esters is described. This coupling process proceeds without a transition-metal catalyst, instead proceeding by electrophilic selenation or iodination of a vinyl boronate complex followed by stereospecific syn or anti elimination. Chiral, nonracemic boronic esters could be coupled with complete enantiospecificity. The process enables the highly stereoselective synthesis of either the E or Z alkene from a single isomer of a vinyl coupling partner.
An expeditious and atom-economical synthesis of a new generation of substituted [4.6.4.6]fenestradienes
Charpenay, Melanie,Boudhar, Aicha,Blond, Gaelle,Suffert, Jean
, p. 4379 - 4382 (2012/06/29)
With finesse and strain: Highly strained derivatives of fenestranes, [4.6.4.6]fenestradienes, have been prepared using a remarkable reaction cascade featuring a 4-exo-dig cyclocarbopalladation, a Sonogashira-type coupling, a regioselective alkynylation, and an 8π/6π electrocyclization sequence. Copyright
