18484-03-2Relevant articles and documents
Solvent-free tetrahydropyranylation (THP) of alcohols and phenols and their regeneration by catalytic aluminum chloride hexahydrate
Namboodiri, Vasudevan V,Varma, Rajender S
, p. 1143 - 1146 (2002)
A catalytic amount of aluminum chloride hexahydrate enables solvent-free tetrahydropyranylation (THP) of alcohols and phenols at moderate temperatures. A simple addition of methanol helps to regenerate the corresponding alcohols and phenols, thus rendering these protection and deprotection sequences as very efficient transformations at high substrate to catalyst ratios.
Copper-Catalyzed Oxidative Acetalization of Boronic Esters: An Umpolung Strategy for Cyclic Acetal Synthesis
Miller, Eric M.,Walczak, MacIej A.
, p. 8230 - 8239 (2020/07/15)
A protocol for the acetalization of boronic esters is described. The reaction is catalyzed by copper, and the conditions proved to be mild and were amenable to a variety of functional groups. We expanded the Chan-Lam coupling to include C(sp3) nucleophiles and converted them into corresponding acetals. This method allows for the orthogonal acetalization of substrates with reactive, acid-sensitive functional groups.
Direct Conversion of TMS-ethers to THP-ethers Catalyzed by {[K.18-Crown-6]Br3}n
Chehardoli, Gholamabbas,Ali Zolfigol, Mohammad,Derakhshanpanah, Fateme
, (2019/04/27)
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