1859-42-3
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Basic information
- Product Name: 2-oxo-3-piperonyliden-pyrrolidin
- Synonyms:
- CAS NO:1859-42-3
- Molecular Formula:
- Molecular Weight: 217.224
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1859-42-3.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: N/A
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 2-oxo-3-piperonyliden-pyrrolidin(CAS DataBase Reference)
- NIST Chemistry Reference: 2-oxo-3-piperonyliden-pyrrolidin(1859-42-3)
- EPA Substance Registry System: 2-oxo-3-piperonyliden-pyrrolidin(1859-42-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1859-42-3(Hazardous Substances Data)
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1859-42-3 Usage
Description
2-oxo-3-piperonyliden-pyrrolidin is a benzylidene lactam compound that functions as an active form of heat shock protein (Hsp) inhibitor II. It is known for its ability to prevent the synthesis of inducible Hsps, such as Hsp105, Hsp72, and Hsp40. 2-oxo-3-piperonyliden-pyrrolidin has demonstrated potential in reducing the thermotolerance of tumors and enhancing the susceptibility of certain strains of fungi to specific treatments.Uses
Used in Pharmaceutical Applications:2-oxo-3-piperonyliden-pyrrolidin is used as an Hsp inhibitor for the purpose of decreasing Hsp72 synthesis in vivo. This action can lead to a reduction in the thermotolerance of tumors in SCC VII tumor-containing mice, potentially making them more susceptible to treatment.
Used in Antifungal Treatments:
In the field of antifungal therapy, 2-oxo-3-piperonyliden-pyrrolidin is used in combination with amphotericin B (AmB) to increase the susceptibility of both AmB-susceptible and AmB-resistant strains of Aspergillus fumigatus. This combination therapy can lead to lower minimum inhibitory concentrations (MICs) for the fungi, enhancing the effectiveness of the treatment.
Used in Cancer Research:
2-oxo-3-piperonyliden-pyrrolidin is also utilized in cancer research as a potential therapeutic agent. By inhibiting the synthesis of inducible Hsps, it may contribute to the development of novel strategies for cancer treatment, particularly in targeting heat shock proteins that are often overexpressed in cancer cells.
Check Digit Verification of cas no
The CAS Registry Mumber 1859-42-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,5 and 9 respectively; the second part has 2 digits, 4 and 2 respectively.Calculate Digit Verification of CAS Registry Number 1859-42:
(6*1)+(5*8)+(4*5)+(3*9)+(2*4)+(1*2)=103
103 % 10 = 3
So 1859-42-3 is a valid CAS Registry Number.
1859-42-3Upstream product
1859-42-3Downstream Products
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2-oxo-3-piperonyliden-pyrrolidin
