186093-95-8

Basic information

• Product Name: 5-[2-(3-Fluoro-4-methoxy-benzoyl)-benzofuran-5-ylmethyl]-thiazolidine-2,4-dione
• Synonyms: 5-[2-(3-Fluoro-4-methoxy-benzoyl)-benzofuran-5-ylmethyl]-thiazolidine-2,4-dione
• CAS NO: 186093-95-8
• Molecular Weight: 399.399
• Mol File: 186093-95-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-[2-(3-Fluoro-4-methoxy-benzoyl)-benzofuran-5-ylmethyl]-thiazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[2-(3-Fluoro-4-methoxy-benzoyl)-benzofuran-5-ylmethyl]-thiazolidine-2,4-dione(186093-95-8)
• EPA Substance Registry System: 5-[2-(3-Fluoro-4-methoxy-benzoyl)-benzofuran-5-ylmethyl]-thiazolidine-2,4-dione(186093-95-8)

Safety Data

• Hazardous Substances Data: 186093-95-8(Hazardous Substances Data)

Upstream product

• 321-28-8 1-fluoro-2-methoxybenzene 
• 3328-70-9 5-formyl-2-hydroxybenzaldehyde 
• 455-91-4 1-(3-fluoro-4-methoxyphenyl)ethanone 
• 350-27-6 2-bromo-1-(3-fluoro-4-methoxyphenyl)ethanone 
• 123-08-0 4-hydroxy-benzaldehyde 
• 186093-84-5 2-(3-Fluoro-4-methoxy-benzoyl)-benzofuran-5-carbaldehyde 

Relevant articles and documents

Synthetic approaches to benzofuran containing Insulin Sensitivity Enhancer compounds for treatment of type II diabetes

The search for Insulin Sensitivity Enhancer (ISE) compounds, for potential use in the treatment of Type II diabetes, has led to the synthesis of compounds that contain a benzofuran spacer between an aryloyl substituent and a 2,4-thiazolidinedione pharmacophore. Sequential combination of haloacetyl aryl substrates with 5-formylsalicylaldehyde gave the desired 2-aryloyl-5-formylbenzofuran intermediates. A related class of compounds, those with a methylene tether between the aromatic moiety and the benzofuran spacer, were also prepared through this strategy.