186466-64-8

Basic information

• Product Name: Carbamic acid, [(1R)-2-hydroxy-1,2-dimethylpropyl]-, 1,1-dimethylethyl ester
• Synonyms: Carbamic acid, [(1R)-2-hydroxy-1,2-dimethylpropyl]-, 1,1-dimethylethyl ester;(R)-tert-butyl 3-hydroxy-3-methylbutan-2-ylcarbamate
• CAS NO: 186466-64-8
• Molecular Formula: C₁₀H₂₁NO₃
• Molecular Weight: 203.27864
• Product Categories: N-BOC
• Mol File: 186466-64-8.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, [(1R)-2-hydroxy-1,2-dimethylpropyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1R)-2-hydroxy-1,2-dimethylpropyl]-, 1,1-dimethylethyl ester(186466-64-8)
• EPA Substance Registry System: Carbamic acid, [(1R)-2-hydroxy-1,2-dimethylpropyl]-, 1,1-dimethylethyl ester(186466-64-8)

Safety Data

• Hazardous Substances Data: 186466-64-8(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 917-54-4 methyllithium 
• 91103-47-8 N-(tert-butoxycarbonyl)-D-alanine methyl ester 
• 74-88-4 methyl iodide 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 1610360-94-5 (R)-N-(3-hydroxy-3-methylbutan-2-yl)-2-nitrobenzenesulfonamide 
• 1610360-88-7 (R)-2,2,3-trimethyl-1-((2-nitrophenyl)sulfonyl)aziridine 
• 600733-91-3 (3R)-3-amino-2-methylbutan-2-ol 
• 1610361-04-0 (R)-N-(3-methyl-3-phenoxybutan-2-yl)-2-nitrobenzenesulfonamide 
• 1428631-14-4 (R)-5-((3-fluorophenyl)ethynyl)-N-(3-methoxy-3-methylbutan-2-yl)picolinamide 
• 1428631-05-3 (R)-N-(3-hydroxy-3-methylbutan-2-yl)-5-(p-tolylethynyl)picolinamide 
• 1428631-09-7 (R)-N-(3-hydroxy-3-methylbutan-2-yl)-5-(m-tolylethynyl)picolinamide 
• 1428631-02-0 (R)-N-(3-hydroxy-3-methylbutan-2-yl)-5-(o-tolylethynyl)picolinamide 
• 1428631-07-5 (R)-5-((2,4-difluorophenyl)ethynyl)-N-(3-hydroxy-3-methylbutan-2-yl)picolinamide 
• 1428631-00-8 (R)-5-((3,5-difluorophenyl)ethynyl)-N-(3-hydroxy-3-methylbutan-2-yl)picolinamide 
• 1428631-08-6 (R)-5-((4-fluorophenyl)ethynyl)-N-(3-hydroxy-3-methylbutan-2-yl)picolinamide 
• 1428631-06-4 (R)-5-((2-fluorophenyl)ethynyl)-N-(3-hydroxy-3-methylbutan-2-yl)picolinamide 
• 1428631-11-1 (R)-N-(3-hydroxy-3-methylbutan-2-yl)-5-(phenylethynyl)picolinamide 
• 1428630-85-6 (R)-5-((3-fluorophenyl)ethynyl)-N-(3-hydroxy-3-methylbutan-2-yl)picolinamide 

Relevant articles and documents

N-1 BRANCHED ALKYL SUBSTITUTED IMIDAZO[4,5-C]QUINOLINE COMPOUNDS, COMPOSITIONS, AND METHODS

Imidazo[4,5-c]quinoline compounds having a substituent that is attached at the N-1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing (or inhibiting) cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.

NOVEL BENZIMIDAZOLE COMPOUND AND MEDICAL USE THEREOF

The present invention provides a medicament for treating a disease involving Nav 1.7 such as neuropathic pain, nociceptive pain, inflammatory pain, small-fiber neuropathy, erythromelalgia, paroxysmal extreme pain disorder, dysuria, and multiple sclerosis, which comprises a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1a, R1b, R1c and R1d are hydrogen, halogen, cyano, C1-4 alkyl, C1-4 alkoxy, or the like, provided that at least one of R1a, R1b, R1c and R1d is C6-10 aryl, C6-10 aryloxy, or the like, R2 and R3 are hydrogen, C1-6 alkyl, C3-10 cycloalkyl, or the like, R4 is hydrogen, C1-6 alkyl, C3-7 cycloalkyl, or the like, m is 1, 2 or 3, L is CR7R8, and R7 and R8 are hydrogen, hydroxyl, C1-4 alkyl, C1-4 alkoxy, or the like.

PYRROLOPYRAZINE KINASE INHIBITORS

The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.