18709-45-0 Usage
Description
2-Phenyl-3H-azirine-3-carboxylic acid methyl ester is a cyclic organic compound with the molecular formula C11H9NO2. It features a reactive three-membered ring containing nitrogen and is a methyl ester derivative of 2-phenyl-3H-azirine-3-carboxylic acid. This chemical is utilized in various fields, including organic synthesis and medicinal chemistry, where it serves as a reagent and intermediate for the synthesis of a wide range of compounds.
Uses
Used in Organic Synthesis:
2-Phenyl-3H-azirine-3-carboxylic acid methyl ester is used as a reagent in organic synthesis for the preparation of various compounds. Its unique structure and reactivity make it a valuable component in creating complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-Phenyl-3H-azirine-3-carboxylic acid methyl ester is employed as an intermediate for the synthesis of pharmaceuticals and biologically active molecules. Its properties allow for the development of new drugs and therapeutic agents.
Used in Pharmaceutical Production:
2-Phenyl-3H-azirine-3-carboxylic acid methyl ester is used as a building block in the preparation of pharmaceuticals. Its incorporation into drug molecules can contribute to the discovery of novel treatments and medications.
Used in Agrochemical Production:
2-Phenyl-3H-azirine-3-carboxylic acid methyl ester is also utilized as a starting material for the production of agrochemicals. Its application in this industry aids in the development of new pesticides, herbicides, and other agricultural chemicals to improve crop protection and yield.
Used in the Production of Fine Chemicals:
2-Phenyl-3H-azirine-3-carboxylic acid methyl ester is employed in the synthesis of fine chemicals, which are high-purity, specialized chemicals used in various industries, including research, pharmaceuticals, and cosmetics. Its versatility and reactivity contribute to the creation of high-quality specialty products.
Check Digit Verification of cas no
The CAS Registry Mumber 18709-45-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,7,0 and 9 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 18709-45:
(7*1)+(6*8)+(5*7)+(4*0)+(3*9)+(2*4)+(1*5)=130
130 % 10 = 0
So 18709-45-0 is a valid CAS Registry Number.
18709-45-0Relevant articles and documents
A novel approach to 5: H -pyrazino[2,3- b] indoles via annulation of 3-diazoindolin-2-imines with 2 H -azirines or 5-alkoxyisoxazoles under Rh(II) catalysis
Ruvinskaya, Julia O.,Rostovskii, Nikolai V.,Filippov, Ilya P.,Khlebnikov, Alexander F.,Novikov, Mikhail S.
, p. 38 - 42 (2017)
A novel one-step method for the preparation of 5H-pyrazino[2,3-b]indoles with different substitution patterns in all rings of the tricyclic system via the Rh2(OAc)4-catalyzed reaction of 2H-azirines with 3-diazoindolin-2-imines is reported. Alkyl 5H-pyrazino[2,3-b]indole-3-carboxylates were also prepared by a one-pot procedure from synthetic equivalents of alkyl 2H-azirine-2-carboxylates, 5-alkoxyisoxazoles. The reactions provide the first examples of the use of Rh(ii) catalysis for intermolecular annulations with 2H-azirines and isoxazoles.
Nucleophile-Induced Rearrangement of 2 H-Azirine-2-carbonyl Azides to 2-(1 H-Tetrazol-1-yl)acetic Acid Derivatives
Efimenko, Nikita I.,Khlebnikov, Alexander F.,Novikov, Mikhail S.,Spiridonova, Dar'ya V.,Tomashenko, Olesya A.
supporting information, p. 6362 - 6366 (2021/09/02)
2H-Azirine-2-carbonyl azides undergo a rearrangement into derivatives of 2-(1H-tetrazol-1-yl)acetic acid when interacting with O- and S-nucleophiles at room temperature. The reaction is catalyzed by tertiary amines or hydrazoic acid. The reaction with primary alcohols and phenols gives alkyl/aryl 2-(1H-tetrazol-1-yl)acetates. Thiophenols react with 2H-azirine-2-carbonyl azides to afford S-aryl 2-(1H-tetrazol-1-yl)ethanethioates. The mechanism of the nucleophile-induced rearrangement of 2H-azirine-2-carbonyl azides is discussed on the basis of DFT calculations as well as kinetic and 15N labeling experiments.
An Azirine Strategy for the Synthesis of Alkyl 4-Amino-5-(trifluoromethyl)-1 H -pyrrole-2-carboxylates
Funt, Liya D.,Tomashenko, Olesya A.,Novikov, Mikhail S.,Khlebnikov, Alexander F.
, p. 4809 - 4822 (2018/12/13)
1-(3,3,3-Trifluoro-2,2-dihydroxypropyl)pyridin-1-ium bromide serves as a trifluoromethyl-containing building block for the preparation of trifluoromethyl-substituted aminopyrroles based on the 2 H -azirine ring expansion strategy. The primary products, 3-
