187091-55-0

Basic information

• Product Name: (S)-1,5-Dibenzyl-4-benzyloxy-5-hydroxy-pyrrolidin-2-one
• Synonyms: (S)-1,5-Dibenzyl-4-benzyloxy-5-hydroxy-pyrrolidin-2-one
• CAS NO: 187091-55-0
• Molecular Weight: 387.478
• Mol File: 187091-55-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S)-1,5-Dibenzyl-4-benzyloxy-5-hydroxy-pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1,5-Dibenzyl-4-benzyloxy-5-hydroxy-pyrrolidin-2-one(187091-55-0)
• EPA Substance Registry System: (S)-1,5-Dibenzyl-4-benzyloxy-5-hydroxy-pyrrolidin-2-one(187091-55-0)

Safety Data

• Hazardous Substances Data: 187091-55-0(Hazardous Substances Data)

Upstream product

• 170711-05-4 (S)-1-benzyl-3-(benzyloxy)pyrrolidine-2,5-dione 
• 129823-21-8 (S)-4-acetoxy-1-benzyl-2,5-pyrrolidinedione 
• 100-39-0 benzyl bromide 
• 1589-82-8 phenylmagnesium bromide 
• 6921-34-2 benzylmagnesium chloride 
• 101469-91-4 (3S)-1-benzyl-3-hydroxypyrrolidine-2,5-dione 

Downstream Products

• 904915-15-7 1-benzyl-4-benzyloxy-5-(hydroxy-phenyl-methyl)-5-methoxy-pyrrolidin-2-one 
• 904915-07-7 (S,E)-1-Benzyl-5-benzylidene-4-(benzyloxy)pyrrolidin-2-one 

Relevant articles and documents

A versatile approach to cis-5-substituted 4-hydroxy-2-pyrrolidinones: asymmetric synthesis of angiogenesis inhibitor streptopyrrolidine

A concise, flexible, and highly diastereoselective approach to cis-5-alkyl-4-hydroxy-2-pyrrolidinones 1 is described. The key step is an ammonium acetate-assisted catalytic hydrogenation of the enamides 9, derived in two steps from malimides 6a,b as we ha

An easy access to protected (4S, 5R)-5-alkyl-4-hydroxy-2-pyrrolidinones and their use as versatile synthetic intermediates

A versatile approach to enantiopure (4S, 5R)-5-alkyl-4-hydroxy-2- pyrrolidinones is described. The key steps involve a regioselective Grignard reagent addition to (S)-malimides, and diastereoselective reductive dehydroxylation of the resulting hemi-azaketals. The flexibility of this methodology has been demonstrated by the synthesis of (2R, 3R)-3-amino-1- benzyl-2-methylpyrrolidine, the parent diamine of antipsychotic agent, emonapride, and the unnatural enantiomer of the β-hydroxy-γ-amino acid residue of hapalosin in lactam form.