18830-44-9Relevant articles and documents
Novel preparation method of 3, 3, 3-trifluoropropionic acid
-
Paragraph 0024; 0026; 0028; 0030; 0032; 0034-0036; 0038-0040, (2020/04/02)
The invention discloses a novel preparation method of 3, 3, 3-trifluoropropionic acid, and relates to the field of medical pesticides. 1, 1-dichloroethylene is used as a raw material to be subjected to an addition reaction with chloroformate or ester under the catalysis of iron powder to obtain trichloropropionate or salt thereof, the trichloropropionate or salt thereof is smoothly subjected to afluorination reaction under proper conditions to efficiently obtain trifluoropropionate or fluorine trifluoropropionate, and the trifluoropropionate or fluorine trifluoropropionate is hydrolyzed to obtain 3, 3, 3-trifluoropropionic acid. In conclusion, the method for preparing trifluoropropionic acid has the advantages of cheap and easily available initial raw materials, simple reaction operation,mild reaction conditions, few steps and high conversion rate, and the conversion rate of the raw material 1, 1-dichloroethylene exceeds 78%.
A 3, 3, 3-three fluorine third method of synthesizing acid methyl ester
-
Paragraph 0031; 0033, (2017/04/04)
The invention discloses a method for synthesizing 3,3,3-trifluoro methyl propionate. The method comprises the following steps of: putting 3,3,3-trifluoropropene serving as a raw material, methyl alcohol, a Pd/C catalyst and a pro-oxidant in a reaction kettle, after introducing 3,3,3-trifluoropropene and oxygen gas, heating up to the temperature of 70-120 DEG C, reacting for 8-12 hours, cooling and filtering reacted liquid; and adding obtained filtrate, protonic acid and the pro-oxidant into a three-neck flask, heating up to the temperature of 60-80 DEG C, dropwise adding hydrogen peroxide, and reacting for 4-8 hours, thereby obtaining 3,3,3-trifluoro methyl propionate. The method has the advantages that the few synthesizing steps (only two steps) are carried out, the yield is high, and the after-treatment is simple.
Bis-exo-2-norbornylboron triflate for stereospecific enolization of 3,3,3-trifluoropropionates
Ramachandran, P. Veeraraghavan,Parthasarathy, Gowrisankar,Gagare, Pravin D.
supporting information; experimental part, p. 4474 - 4477 (2010/12/24)
The first boron-mediated enolization - aldolization of 3,3,3- trifluoropropionates has been reported. The preparation and application of bis-exo-bicyclo[2.2.1]heptan-2-ylboron triflate as a superior reagent for diastereospecific enolization has also been described.