188612-59-1Relevant articles and documents
A new route to the antitumour drug temozolomide, but not thiotemozolomide
Wang, Yongfeng,Lowe, Philip R.,Thomson, William T.,Clark, Jonathan,Stevens, Malcolm F. G.
, p. 363 - 364 (1997)
Interaction of 5-aminoimidazole-4-carboxamide with alkyl isocyanates yields N-substituted 1-carbamoylimidazoles which can be cyclised to imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-ones, including temozolomide 3a, on nitrosation; a similar reaction with methyl isothiocyanate, followed by nitrosation, affords the nitrosomethylamino derivative 11 of a new ring-system, imidazo[l,5-b][1,2,4]thiadiazole.