189954-66-3

Basic information

• Product Name: 2(5H)-Furanone, 5,5-dimethyl-3-(1-methylethoxy)-4-[4-(methylsulfonyl)phenyl]-
• CAS NO: 189954-66-3
• Molecular Formula: C16H20O5S
• Molecular Weight: 324.398
• Mol File: 189954-66-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2(5H)-Furanone, 5,5-dimethyl-3-(1-methylethoxy)-4-[4-(methylsulfonyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(5H)-Furanone, 5,5-dimethyl-3-(1-methylethoxy)-4-[4-(methylsulfonyl)phenyl]-(189954-66-3)
• EPA Substance Registry System: 2(5H)-Furanone, 5,5-dimethyl-3-(1-methylethoxy)-4-[4-(methylsulfonyl)phenyl]-(189954-66-3)

Safety Data

• Hazardous Substances Data: 189954-66-3(Hazardous Substances Data)

Upstream product

• 400-38-4 isopropyl Trifluoroacetate 
• 180048-73-1 2-hydroxy-2-methyl-1-(4-(methylsulfonyl)-phenyl)propan-1-one 
• 13831-31-7 Acetoxyacetyl chloride 
• 100-68-5 methyl-phenyl-thioether 
• 610785-95-0 3-isopropoxy-5,5-dimethyl-4-(4-methylsulfanylphenyl)-2,5-dihydro-2-furanone 
• 190966-51-9 isopropoxy-acetic acid 2-(4-methanesulfonyl-phenyl)-1,1-dimethyl-2-oxo-ethyl ester 
• 610785-96-1 1,1-dimethyl-2-[(4-methylsulfanyl)phenyl]-2-oxoethyl 2-isopropoxyacetate 
• 71867-98-6 2-hydroxy-2-methyl-1-(4-(methylthio)phenyl)-propan-1-one 
• 53207-58-2 2-methyl-1-(4-(methylthio)phenyl)-propan-1-one 
• 33445-07-7 2-isopropoxyacetic acid 

Relevant articles and documents

An improved and practical synthesis of 5,5-dimethyl-3-(2-propoxy)-4-(4-methanesulfonylphenyl)-2-(5H)-furanone (DFP - A selective inhibitor of cyclooxygenase-2)

DFP, a highly selective and potent COX-2 inhibitor, has been synthesized by a modified approach. Three modifications of the existing method enabled us to prepare DFP in good quantity.

SAR in the alkoxy lactone series: The discovery of DFP, a potent and orally active COX-2 inhibitor

Extensive SAR has been established in the alkoxy lactone series and this has lead to the discovery of DFP (5,5-dimethyl-3-(2-propoxy)-4- methanesulfonylphenyl)-2(5H)-furanone), a potent COX-2 inhibitor exhibiting in vivo efficacy in all models studied.

3,4-diaryl-2-hydroxy-2,5-dihydrofurans as prodrugs to COX-2 inhibitors

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.