19036-99-8

Basic information

• Product Name: (E)-1-(4-Methoxyphenyl)-2-(2-pyridyl)ethene
• Synonyms: (E)-1-(4-Methoxyphenyl)-2-(2-pyridyl)ethene;2-[(E)-2-(4-Methoxyphenyl)ethenyl]pyridine;(E)-2-(4-Methoxystyryl)pyridine
• CAS NO: 19036-99-8
• Molecular Formula: C₁₄H₁₃NO
• Molecular Weight: 211.26
• Mol File: 19036-99-8.mol
• Article Data: 17

Chemical Properties

• Melting Point: 98-100 °C
• Boiling Point: 354.2±11.0 °C(Predicted)
• Appearance: /
• Density: 1.112±0.06 g/cm3(Predicted)
• PKA: 4.71±0.10(Predicted)
• CAS DataBase Reference: (E)-1-(4-Methoxyphenyl)-2-(2-pyridyl)ethene(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(4-Methoxyphenyl)-2-(2-pyridyl)ethene(19036-99-8)
• EPA Substance Registry System: (E)-1-(4-Methoxyphenyl)-2-(2-pyridyl)ethene(19036-99-8)

Safety Data

• Hazardous Substances Data: 19036-99-8(Hazardous Substances Data)

Usage

Description

(E)-1-(4-Methoxyphenyl)-2-(2-pyridyl)ethene, also known as 2-(4-Methoxyphenyl)-1-(2-pyridyl)ethene or trans-4'-methoxystilbene, is a chemical compound with the molecular formula C17H15NO. It is a derivative of stilbene, characterized by a central ethene double bond and two aromatic rings. (E)-1-(4-Methoxyphenyl)-2-(2-pyridyl)ethene is recognized for its potential biological activities, such as inhibiting cancer cell growth, and is also being studied for its antioxidant and anti-inflammatory properties. Furthermore, it has been investigated for use as a fluorescent probe in biochemical and biomedical research.

Uses

Used in Pharmaceutical Research:
(E)-1-(4-Methoxyphenyl)-2-(2-pyridyl)ethene is used as a compound in pharmaceutical research for its potential to inhibit the growth of cancer cells, making it a candidate for the development of novel anticancer drugs.
Used in Organic Synthesis:
In the field of organic synthesis, (E)-1-(4-Methoxyphenyl)-2-(2-pyridyl)ethene is utilized as a key intermediate or building block for the creation of more complex molecules with various applications.
Used in Biochemical and Biomedical Studies:
(E)-1-(4-Methoxyphenyl)-2-(2-pyridyl)ethene is used as a fluorescent probe in biochemical and biomedical studies, where its properties can be harnessed to track and visualize specific biological processes or interactions within living systems.
Used in Antioxidant and Anti-Inflammatory Applications:
(E)-1-(4-Methoxyphenyl)-2-(2-pyridyl)ethene is also being explored for its potential antioxidant and anti-inflammatory properties, which could lead to its use in the development of treatments for conditions associated with oxidative stress and inflammation.

Upstream product

• 100-69-6 2-vinylpyridine 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 38700-15-1 triphenyl-(2-pyridylmethyl)phosphonium chloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 100-66-3 methoxybenzene 
• 931-19-1 2-methylpyridine N-oxide 
• 105-13-5 4-Methoxybenzyl alcohol 
• 694-59-7 pyridine N-oxide 
• 5720-07-0 4-methoxyphenylboronic acid 
• 99662-46-1 triphenyl(pyridin-2-ylmethyl)phosphonium chloride hydrochloride 
• 99-96-7 4-hydroxy-benzoic acid 
• 824-94-2 p-methoxybenzyl chloride 
• 121-98-2 methyl 4-methoxybenzoate 
• 1121-60-4 pyridine-2-carbaldehyde 

Downstream Products

• 71413-38-2 RhBr₂(P((CH₂)3CH₃)3)2(C₅H₄NCHC(C₆H₄OCH₃)) 
• 1251668-19-5 2-(2,2-di(4-methoxyphenyl)vinyl)pyridine 
• 26573-47-7 1-[2-(4-methoxy-phenyl)-indolizin-3-yl]-ethanone 
• 77377-07-2 (E)-4-(2-(pyridin-2-yl)vinyl)phenol 

Relevant articles and documents

A new insight into the push-pull effect of substituents via the stilbene-like model compounds

In this paper, authors report on 1-pyridyl-2-arylethenes, 1-furyl-2-arylethylenes, 1,2-diphenylpropylenes and substituted cinnamyl anilines as stilbene-like model compounds to investigate the factors dominating the push-pull effect of substituents via usi

Water-Sculpting of a Heterogeneous Nanoparticle Precatalyst for Mizoroki-Heck Couplings under Aqueous Micellar Catalysis Conditions

Powdery, spherical nanoparticles (NPs) containing ppm levels of palladium ligated by t-Bu3P, derived from FeCl3, upon simple exposure to water undergo a remarkable alteration in their morphology leading to nanorods that catalyze Mizoroki-Heck (MH) couplings. Such NP alteration is general, shown to occur with three unrelated phosphine ligand-containing NPs. Each catalyst has been studied using X-ray photoelectron spectroscopy (XPS), energy-dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), and cryogenic transmission electron microscopy (cryo-TEM) analyses. Couplings that rely specifically on NPs containing t-Bu3P-ligated Pd occur under aqueous micellar catalysis conditions between room temperature and 45 °C, and show broad substrate scope. Other key features associated with this new technology include low residual Pd in the product, recycling of the aqueous reaction medium, and an associated low E Factor. Synthesis of the precursor to galipinine, a member of the Hancock family of alkaloids, is suggestive of potential industrial applications.

Iron-Catalyzed Coupling of Methyl N-Heteroarenes with Primary Alcohols: Direct Access to E-Selective Olefins

An efficient Fe-catalyzed system is reported for direct α-olefination of methyl-substituted N-heteroarenes with primary alcohols. The catalytic dehydrogenative coupling enables a series of functionalized E-olefinated N-heteroaromatics with excellent selectivity (>99%). Initial mechanistic studies including deuterium-labeling experiments provide evidence for the participation of the benzylic C-H/D bond of alcohols.