190845-24-0

Basic information

• Product Name: 2-(2-Hydroxymethyl-5-trifluoromethyl-phenylamino)-benzoic acid methyl ester
• Synonyms: 2-(2-Hydroxymethyl-5-trifluoromethyl-phenylamino)-benzoic acid methyl ester
• CAS NO: 190845-24-0
• Molecular Weight: 325.287
• Mol File: 190845-24-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(2-Hydroxymethyl-5-trifluoromethyl-phenylamino)-benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Hydroxymethyl-5-trifluoromethyl-phenylamino)-benzoic acid methyl ester(190845-24-0)
• EPA Substance Registry System: 2-(2-Hydroxymethyl-5-trifluoromethyl-phenylamino)-benzoic acid methyl ester(190845-24-0)

Safety Data

• Hazardous Substances Data: 190845-24-0(Hazardous Substances Data)

Upstream product

• 402-13-1 2-amino-4-trifluoromethylbenzoic acid 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 188054-34-4 4-(trifluoromethyl)-2-{[2-(methoxycarbonyl)phenyl]amino}benzoic acid 

Downstream Products

• 188054-42-4 2-(2-Formyl-5-trifluoromethyl-phenylamino)-benzoic acid methyl ester 

Relevant articles and documents

A new synthesis of substituted acridine-4-carboxylic acids and the anticancer drug N-[2-dimethylamino)ethyl]acridine-4-carboxamide (DACA)

A new synthesis of substituted acridine-4-carboxylic acids 2 from methyl 2-[N-(2-carboxyphenyl)amino]benzoates (4) is reported, via NaBH4 reduction of the corresponding imidazolides (5), oxidation of the resulting alcohols 6 to aldehyde 7, and cyclisation of these with trifluoroacetic acid to the methyl acridine-4-carboxylates (8), followed by base hydrolysis. Direct amidation of 8a provides a new route to the clinical anticancer drug DACA (3) which avoids use of the irritant acid 2a.