1911578-98-7Relevant articles and documents
Dynamic kinetic resolution method for tail chain of Remdesivir phosphoric acid intermediate
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Paragraph 0049-0052, (2021/09/21)
The invention relates to a drug intermediate of an RNA polymerase inhibitor, in particular to an intermediate of Remdesivir phosphate and a preparation method of the intermediate. According to the method, a compound Sp/Rp epimerization mixture in a formula (I) is crystallized under a dynamic kinetic resolution condition, so that the Rp single configuration isomer, in a formula (I'), of the Remdesivir intermediate is obtained. In the synthesis process, an epimerization mixture of the compound shown in the formula (I) is finally converted into a single-configuration I'compound through crystallization-induced epimerization under the dynamic kinetic resolution condition, so that the total yield of the reaction is increased, the utilization rate of raw materials is increased, and the process is more environmentally friendly and efficient.
Preparation method of (by machine translation)
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Paragraph 0008; 0018-0019; 0023-0024; 0027-0028, (2020/05/30)
To the method disclosed by the invention, compound, compound, and compound V react IV; through acid hydrolysis to obtain compound IV compound III; compound III is subjected to further resolution under the action of a base, and the method disclosed by the invention is suitable for industrialized large-scale production II by avoiding the use, of genotoxic nitro substituent to reduce the risk I. of genotoxic impurities. (by machine translation)
THIARABINE- AND THIARABINE PRODRUG-BASED TREATMENTS
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, (2020/12/29)
The present disclosure is concerned with combination therapies that include sulfur- based nucleotide and nucleoside compounds for the treatment of various cancers such as, for example, sarcomas, carcinomas, hematological cancers, solid tumors, breast cancer, cervical cancer, gastrointestinal cancer, colorectal cancer, brain cancer, skin cancer, prostate cancer, ovarian cancer, bladder cancer, thyroid cancer, testicular cancer, pancreatic cancer, endometrial cancer, melanomas, gliomas, leukemias, lymphomas, chronic myeloproliferative disorders, myelodysplastic syndromes, myeloproliferative neoplasms, and plasma cell neoplasms (myelomas). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.