19178-21-3

Basic information

• Product Name: 2-Methyl-5,6,7,8-tetrahydro-quinazolin-4-ol
• Synonyms: 2-Methyl-5,6,7,8-tetrahydro-quinazolin-4-ol;2-Methyl-5,6,7,8-tetrahydro-3H-quinazolin-4-one
• CAS NO: 19178-21-3
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 164.20438
• Mol File: 19178-21-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 208-209 °C
• Boiling Point: 291.2°Cat760mmHg
• Flash Point: 129.9°C
• Appearance: /
• Density: 1.3g/cm³
• Vapor Pressure: 0.00198mmHg at 25°C
• Refractive Index: 1.644
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 2.69±0.20(Predicted)
• CAS DataBase Reference: 2-Methyl-5,6,7,8-tetrahydro-quinazolin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-5,6,7,8-tetrahydro-quinazolin-4-ol(19178-21-3)
• EPA Substance Registry System: 2-Methyl-5,6,7,8-tetrahydro-quinazolin-4-ol(19178-21-3)

Safety Data

• Hazardous Substances Data: 19178-21-3(Hazardous Substances Data)

Usage

General Description

2-Methyl-5,6,7,8-tetrahydro-quinazolin-4-ol, also known as 5-Methyl-7,8-dihydro-4H-quinazolin-4-one, is an organic compound with the formula C10H12N2O. It is a derivative of quinazolinone and is a cyclic amine and alcohol. This chemical is used in the pharmaceutical industry and is known for its potential as an antiviral and anticancer agent. It has also been studied for its possible role in treating neurological disorders and epilepsy. The compound's structure and bioactivity make it an interesting target for further study and potential applications in medicine.

InChI:InChI=1/C9H12N2O/c1-6-10-8-5-3-2-4-7(8)9(12)11-6/h2-5H2,1H3,(H,10,11,12)

Upstream product

• 143-37-3 acetamidine 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 105550-62-7 2-Methyl-2,3,5,6,7,8-hexahydro-1H-quinazolin-4-one 
• 124-42-5 acetamidine hydrochloride 
• 141419-94-5 ethyl 4-oxotetrahydro-2H-pyran-3-carboxylate 
• 68965-62-8 2-bromocyclohex-1-enecarboxylic acid 
• 62360-62-7 7-exo-bromo-7-endo-fluorobicyclo<4.1.0>heptane 
• 1404219-84-6 4-fluoro-2-methyl-5,6,7,8-tetrahydroquinazoline 1-oxide 

Downstream Products

• 90561-38-9 4-chloro-2-methyl-5,6,7,8-tetrahydroquinazoline 

Relevant articles and documents

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Microwave-assisted copper-powder-catalyzed synthesis of pyrimidinones from β-bromo α,β-unsaturated carboxylic acids and amidines

β-Bromo α,β-unsaturated carboxylic acids were coupled and cyclized with amidine hydrochlorides by microwave irradiation in the presence of catalytic amounts of copper powder and a base to give the corresponding pyrimidinones in high yields. Georg Thieme Verlag Stuttgart New York.

Easy and efficient copper-catalyzed synthesis of bicyclic pyrimidinones under mild conditions

A simple and efficient copper-catalyzed method has been developed for synthesis of bicyclic pyrimidinones containing six-, seven-, eight-membered rings under mild conditions. The protocol uses readily available 2-bromocycloalk-1-enecarboxylic acids, amidines, and guanidines as the starting materials, copper-catalyzed cascade couplings provide the corresponding bicyclic pyrimidinones without addition of any ligand or additive, and the method is of economical and practical advantages. Georg Thieme Verlag Stuttgart New York.