192070-12-5

Basic information

• Product Name: 3'-O-{N_α-(3,4-dimethoxy-6-nitrobenzyloxycarbonyl)-N_ε-[5-(dimethylamino)-1-naphthalenesulfonyl]-L-lysine-L-proline}-5'O-(tert-butyldiphenylsilyl)thymidine
• Synonyms: 3'-O-{N_α-(3,4-dimethoxy-6-nitrobenzyloxycarbonyl)-N_ε-[5-(dimethylamino)-1-naphthalenesulfonyl]-L-lysine-L-proline}-5'O-(tert-butyldiphenylsilyl)thymidine
• CAS NO: 192070-12-5
• Molecular Weight: 1178.4
• Mol File: 192070-12-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3'-O-{N_α-(3,4-dimethoxy-6-nitrobenzyloxycarbonyl)-N_ε-[5-(dimethylamino)-1-naphthalenesulfonyl]-L-lysine-L-proline}-5'O-(tert-butyldiphenylsilyl)thymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-O-{N_α-(3,4-dimethoxy-6-nitrobenzyloxycarbonyl)-N_ε-[5-(dimethylamino)-1-naphthalenesulfonyl]-L-lysine-L-proline}-5'O-(tert-butyldiphenylsilyl)thymidine(192070-12-5)
• EPA Substance Registry System: 3'-O-{N_α-(3,4-dimethoxy-6-nitrobenzyloxycarbonyl)-N_ε-[5-(dimethylamino)-1-naphthalenesulfonyl]-L-lysine-L-proline}-5'O-(tert-butyldiphenylsilyl)thymidine(192070-12-5)

Safety Data

• Hazardous Substances Data: 192070-12-5(Hazardous Substances Data)

Upstream product

• 192070-15-8 (S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester 1-[1-(3,5-dimethoxy-phenyl)-1-methyl-ethyl] ester 
• 185504-01-2 Boc-L-Lys(DANS)-OH 
• 101527-40-6 5'-O-tert-butyldiphenylsilylthymidine 
• 13734-28-6 Boc-Lys-OH 
• 1101-84-4 N^(ε)-5-(dimethylamino)naphthalene-1-sulfonyl-L-lysine 
• 605-65-2 5-(dimethylamino)naphth-1-ylsulfonyl chloride 
• 192070-14-7 (S)-Pyrrolidine-2-carboxylic acid (2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 192070-13-6 (S)-2-(4,5-Dimethoxy-2-nitro-benzyloxycarbonylamino)-6-(5-dimethylamino-naphthalene-1-sulfonylamino)-hexanoic acid 

Downstream Products

• 101527-40-6 5'-O-tert-butyldiphenylsilylthymidine 

Relevant articles and documents

An approach to photolabile, fluorescent protecting groups

The photolablie and fluorescent system 1 was prepared via a convergent route which involved thymidine 3'-functionalized with a proline residue. Photodecomposition of 1 was examined using 360 nm irradiation. Without any additives, 5'-silylated thymidine was not formed, but the N(α)-deprotected cyclization precursor II accumulated instead. However, in the presence of ethanolamine, 5'-silylated thymidine formed at a rate which increases with the concentration of ethanolamine.