1928-81-0

Basic information

• Product Name: 6-PIPERIDINOPURINE
• Synonyms: 6-PIPERIDINOPURINE;6-PIPERIDINO-1-PURINE
• CAS NO: 1928-81-0
• Molecular Formula: C₁₀H₁₃N₅
• Molecular Weight: 203.24
• Mol File: 1928-81-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 330.8°Cat760mmHg
• Flash Point: 153.8°C
• Appearance: /
• Density: 1.47g/cm³
• Vapor Pressure: 1.27E-09mmHg at 25°C
• Refractive Index: 1.672
• CAS DataBase Reference: 6-PIPERIDINOPURINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-PIPERIDINOPURINE(1928-81-0)
• EPA Substance Registry System: 6-PIPERIDINOPURINE(1928-81-0)

Safety Data

• Hazardous Substances Data: 1928-81-0(Hazardous Substances Data)

Usage

Description

6-PIPERIDINOPURINE, with the molecular formula C10H14N4O, is a heterocyclic compound characterized by the presence of a purine ring to which a piperidine group is attached. This versatile chemical serves as a fundamental building block in the synthesis of a variety of pharmaceuticals, particularly those with antiviral and anticancer properties. Additionally, it has garnered interest for its potential as a receptor agonist, offering therapeutic benefits in the treatment of central nervous system disorders. Its multifaceted utility underscores its importance in medicinal chemistry.

Uses

Used in Pharmaceutical Synthesis:
6-PIPERIDINOPURINE is utilized as a key building block in the creation of various pharmaceuticals, specifically for the development of antiviral and anticancer agents. Its unique structure allows for the design of compounds that can target specific biological pathways, thereby enhancing the effectiveness of treatments in these areas.
Used in Antiviral Applications:
In the field of antiviral drug development, 6-PIPERIDINOPURINE is employed as a precursor for the synthesis of compounds that can inhibit viral replication and reduce the severity of viral infections. Its incorporation into antiviral medications aims to provide new treatment options for patients suffering from viral diseases.
Used in Anticancer Applications:
6-PIPERIDINOPURINE also serves as a component in the synthesis of anticancer drugs, where it contributes to the development of molecules that can target and eliminate cancer cells while minimizing damage to healthy cells. This application underscores its potential in advancing cancer therapies.
Used in Central Nervous System Disorder Treatment:
6-PIPERIDINOPURINE is studied for its potential as a receptor agonist in the treatment of central nervous system disorders. Its use in this context is aimed at modulating specific receptors to alleviate symptoms and improve the quality of life for patients with such disorders.

InChI:InChI=1/C10H13N5/c1-2-4-15(5-3-1)10-8-9(12-6-11-8)13-7-14-10/h6-7H,1-5H2,(H,11,12,13,14)

Upstream product

• 110-89-4 piperidine 
• 608-09-3 (7⁽⁹⁾H-purin-6-ylsulfanyl)-acetic acid 
• 4854-10-8 2-chloro-6-piperidin-1-yl-7⁽⁹⁾H-purine 
• 99988-37-1 2-methylsulfanyl-6-piperidino-7⁽⁹⁾H-purine 
• 4010-80-4 2,8-dichloro-6-piperidin-1-yl-7⁽⁹⁾H-purine 
• 87-42-3 6-chloro-7H-purine 
• 68-94-0 hypoxanthine 
• 2562-52-9 2,6,8-trichloro-7H-purine 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 81693-59-6 5-amino-4-(cyanoformimidoyl)-1H-imidazole 
• 87-42-3 6-chloropurine 

Downstream Products

• 41552-92-5 6-(piperidin-1-yl)-9-(β-D-ribofuranosyl)purine 
• 101155-42-4 Phosphoric acid (3aR,4R,6S,6aR)-2,2-dimethyl-6-(6-piperidin-1-yl-purin-9-yl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-fluoro-phenyl ester; compound with triethyl-amine 

Relevant articles and documents

6-Substituted purines as ROCK inhibitors with anti-metastatic activity

Rho-associated serine/threonine kinases (ROCKs) are principal regulators of the actin cytoskeleton that regulate the contractility, shape, motility, and invasion of cells. We explored the relationships between structure and anti-ROCK2 activity in a group

Reactions of Adenine and Its N-Exo Substituted Analogues with Phenyl Glycidyl Ether

Abstract: The features of reactions of adenine with phenyl glycidyl ether depending on the solvent nature were studied. In DMF in the presence of K2CO3, an N9-alkyl derivative, an experimental antiviral drug 9-(2-hydroxy-3-phenoxypropyl)adenine, was formed predominantly. During alkylation in acetic acid, besides N9-, N3-, and N7-alkylation products were also isolated. Alkylation of 6-[alkyl(dialkyl)amino]purines with phenyl glycidyl ether in DMF produced N-exo substituted 9-(2-hydroxy-3-phenoxypropyl)adenine analogues.

HFIP Promoted Low-Temperature SNAr of Chloroheteroarenes Using Thiols and Amines

A highly efficient and an unprecedented hexafluoro-2-propanol, promoting low-temperature aromatic nucleophilic substitutions of chloroheteroarenes, has been performed using thiols and (secondary) amines under base-free and metal-free conditions. The developed protocol also provides excellent regio-control for the selective functionalization of dichloroheteroarenes, while the utility of the protocol was demonstrated by the modification of a commercially available drug ceritinib.