193976-47-5

Basic information

• Product Name: 2(1H)-Naphthalenone, 3,4-dihydro-1-[3-[3-(trifluoromethyl)phenyl]-2-propynyl]-
• CAS NO: 193976-47-5
• Molecular Formula: C20H15F3O
• Molecular Weight: 328.334
• Mol File: 193976-47-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2(1H)-Naphthalenone, 3,4-dihydro-1-[3-[3-(trifluoromethyl)phenyl]-2-propynyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Naphthalenone, 3,4-dihydro-1-[3-[3-(trifluoromethyl)phenyl]-2-propynyl]-(193976-47-5)
• EPA Substance Registry System: 2(1H)-Naphthalenone, 3,4-dihydro-1-[3-[3-(trifluoromethyl)phenyl]-2-propynyl]-(193976-47-5)

Safety Data

• Hazardous Substances Data: 193976-47-5(Hazardous Substances Data)

Upstream product

• 21403-95-2 1-(3,4-dihydronaphthalene-2-yl)pyrrolidine 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 220043-97-0 1-(prop-2-yn-1-yl)-tetralone 

Relevant articles and documents

Synthesis of functionalised furans and pyrroles through annulation reactions of 4-pentynones

A new approach to 4-pentynones through palladium-catalysed coupling reaction of the ready available 2-propynyl ketones with aryl iodides and/or vinyl triflates is proposed. Annulation reactions of both 2-propynyl ketones and 4-pentynones gave functionalised furans using potassium tert-butoxide in DMF and functionalised pyrroles in the presence of benzylamine or ammonia, respectively in good to high yields. The methodology has been extended to the preparation of 17β-hydroxyandrost-4-en[3,2-b](5-methyl)furan and to 17β- hydroxyandrost-4-en[3,2-b](1-benzyl-5-methyl)pyrrole. A different reaction pattern was observed when the 4-pentynones were treated with sodium methoxide in MeOH. The influence of the reaction medium on the outcome of the annulation reaction in the case of one 2-pentyn-1,6-dione (heteroannulation vs. carbocyclization) is also shown.