195457-70-6

Basic information

• Product Name: 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID
• Synonyms: 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID;3'-(TRIFLUOROMETHYL)-1,1'-BIPHENYL-4-CARBOXYLIC ACID;AKOS BAR-0024;[1,1'-BIPHENYL]-4-CARBOXYLIC ACID, 3'-(TRIFLUOROMETHYL)-;RARECHEM AL BE 1367;4-(3-(Trifluoromethyl)phenyl)benzoic acid
• CAS NO: 195457-70-6
• Molecular Formula: C₁₄H₉F₃O₂
• Molecular Weight: 266.22
• Product Categories: pharmacetical
• Mol File: 195457-70-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 375.7 °C at 760 mmHg
• Flash Point: 181 °C
• Appearance: /
• Density: 1.326 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID(195457-70-6)
• EPA Substance Registry System: 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID(195457-70-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 195457-70-6(Hazardous Substances Data)

Usage

Description

3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID, also known as 4-(3-Trifluoromethylphenyl)benzoic acid, is an organic compound with a unique molecular structure featuring a trifluoromethyl group attached to a biphenyl ring and a carboxylic acid functional group. 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID is known for its potential applications in various chemical and pharmaceutical processes due to its specific chemical properties.

Uses

Used in Pharmaceutical Industry:
3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID is used as a reagent for the synthesis of aryl-substituted aspartic acid and diaminopropionic acid derivatives. These derivatives serve as inhibitors of glutamate transporter EAAT-2 (Excitatory amino acid transporters 2), which play a crucial role in the regulation of glutamate levels in the brain. By inhibiting EAAT-2, these derivatives can potentially be used in the development of treatments for neurological disorders associated with glutamate dysregulation.

Upstream product

• 619-58-9 4-iodobenzoic acid 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 
• 586-76-5 4-Bromobenzoic acid 

Downstream Products

• 1373523-84-2 (3S)-N-Hydroxy-1-(phenylcarbonyl)-N-(1-{[3'-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine 
• 1373523-83-1 (3S)-N-Ethyl-1-(phenylcarbonyl)-N-(1-{[3'-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine 

Relevant articles and documents

PIPERIDIN-4-YL-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows: wherein Y, Z, and R are defined herein.

Amide bridged piphenyl or biazaphenyl derivatives

This invention is concerned with compounds of the formula wherein one of R5, R6 and R7 is and R1 to R13, X1, X2, m and n are defined in the description, and all pharmaceutically