19578-80-4Relevant articles and documents
Ortho-selective cross coupling of dibromophenols and dibromoanilines with grignard reagents in the presence of palladium catalysts bearing hydroxylated oligoarene-type phosphine
Ishikawa, Shunpei,Manabe, Kei
, p. 1304 - 1305 (2007)
p-Terphenylphosphines with a hydroxy group were used as ligands for palladium in the catalytic cross coupling of dibromophenols and dibromoanilines with Grignard reagents. High ortho-selectivity that cannot be achieved with other phosphine ligands was observed. Copyright
Synthesis of substituted asymmetrical biphenyl amino esters as alpha helix mimetics
Williams, Anna B.,Hanson, Robert N.
experimental part, p. 5406 - 5414 (2012/09/08)
As part of our ongoing project to develop new molecular probes for estrogen receptor-alpha, we are exploring the utility of internally-substituted asymmetric biphenyls as a proteomimetic scaffold. In this study, we describe synthetic methods for preparing
Hydroxylated terphenylphosphine ligands for palladium-catalyzed ortho-selective cross-coupling of dibromophenols, dibromoanilines, and their congeners with Grignard reagents
Ishikawa, Shunpei,Manabe, Kei
experimental part, p. 10156 - 10163 (2012/02/13)
p-Terphenylphosphines bearing one or two hydroxy groups were used as ligands to palladium in the cross-coupling of dibromophenols, dibromoanilines, and their congeners with Grignard reagents. High ortho-selectivity that cannot be achieved using other phosphine ligands was observed. ortho-Preference was also observed in competitive cross-coupling reactions of two substrates. A significant effect of the concentration of the Grignard reagent on the ortho-selectivity was observed, when the hydroxylated terphenylphosphines were used. Kinetic studies on this effect showed that high concentrations of the Grignard reagent retard the cross-coupling reaction only at the para-position, but not at the ortho-position.
