197438-91-8

Basic information

• Product Name: (4-Fluorophenyl)[4-(methylsulfonyl)phenyl]ketone
• Synonyms: (4-Fluorophenyl)[4-(methylsulfonyl)phenyl]ketone
• CAS NO: 197438-91-8
• Molecular Weight: 278.304
• Mol File: 197438-91-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (4-Fluorophenyl)[4-(methylsulfonyl)phenyl]ketone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Fluorophenyl)[4-(methylsulfonyl)phenyl]ketone(197438-91-8)
• EPA Substance Registry System: (4-Fluorophenyl)[4-(methylsulfonyl)phenyl]ketone(197438-91-8)

Safety Data

• Hazardous Substances Data: 197438-91-8(Hazardous Substances Data)

Upstream product

• 724-88-9 4’-(methylthio)phenyl(4’-fluorophenyl)methanone 

Relevant articles and documents

Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(Aryloyl)phenyl methyl sulfones

Following our previous research on anti-inflammatory drugs (NSAIDs), we report on the design and synthesis of 4-(aryloyl)phenyl methyl sulfones. These substances were characterized for their capacity to inhibit cyclooxygenase (COX-1 and COX-2) isoenzymes. Molecular modeling studies showed that the methylsulfone group of these compounds was inserted deep in the pocket of the human COX-2 binding site, in an orientation that precludes hydrogen bonding with Arg120, Ser353, and Tyr355 through their oxygen atoms. The N-arylindole 33 was the most potent inhibitor of COX-2 and also the most selective (COX-1/COX-2 IC50 ratio was 262). The indole derivative 33 was further tested in vivo for its anti-inflammatory activity in rats. This compound showed greater inhibitory activity than ibuprofen. Other compounds (20, 26, 9, and 30) showed strong activity against carrageenan-induced inflammation. The latter compounds showed a weak capacity to inhibit the proliferation of human cell lines K562, NCI-H460, and HT-29 in vitro.

Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics

The present invention relates to derivatives of the formula the process for their preparation, and to their uses in therapeutics, especially as drugs with anti-inflammatory, analgesic and chemopreventive properties.

Carbocyclic diarylmethylene derivatives, processes for their preparation and their uses in therapeutics

The present invention relates to the carbocyclic diarylmethylene derivatives of formula (I): STR1 and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.