197502-55-9

Basic information

• Product Name: Piperazine, 1-(4-chlorophenyl)-4-methyl-
• CAS NO: 197502-55-9
• Molecular Formula: C11H15ClN2
• Molecular Weight: 210.706
• Mol File: 197502-55-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Piperazine, 1-(4-chlorophenyl)-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-(4-chlorophenyl)-4-methyl-(197502-55-9)
• EPA Substance Registry System: Piperazine, 1-(4-chlorophenyl)-4-methyl-(197502-55-9)

Safety Data

• Hazardous Substances Data: 197502-55-9(Hazardous Substances Data)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 106-46-7 para-dichlorobenzene 
• 50-00-0 formaldehyd 
• 38212-33-8 4-(4-chlorophenyl) piperazine 
• 110-91-8 morpholine 
• 29540-84-9 4-chlorophenyl trifluoromethanesulfonate 
• 95-76-1 m,p-dichloroaniline 
• 463-57-0 methanediol 

Relevant articles and documents

N-heterocyclic carbene-Pd(II)-2-methyl-4,5-dihydrooxazole complex-catalyzed highly chemoselective mono-amination of dichlorobenzenes

The palladium-catalyzed chemoselective mono-amination of dichlorobenzenes was reported in this paper. Under the suitable conditions, all reactions involving the three isomers of dichlorobenzenes with various secondary and primary amines in the presence of

Gram-scale synthesis of N-aryl- and N-aryl-N′-methylpiperazines on a novel, water-swellable, oxethane-linked poly(ethylene glycol) high-loading resin

A new methodology for the synthesis of N-arylpiperazines was developed using a poly(ethylene glycol)-derived solid support. The reactions proceeded in up to 60% overall yield over four steps. The scope and limitations of the method are discussed, as well as the utility of 13C gel-phase NMR spectroscopy for reaction monitoring. Georg Thieme Verlag Stuttgart.

Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP)

DMPP is a well-known nicotinic agonist that does not fit any proposed pharmacophore for nicotinic binding and represents a unique ligand among the hundreds of nicotinic agonists studied in the past decades. A systematic modulation of the chemical structure of DMPP, aimed to establish its structure-affinity relationships, is reported. The research has allowed to identify molecules such as 11c, 13c, 14c, and 28c, with affinities for α4β2 receptors in the low nanomolar range, some 2 orders of magnitude lower than the lead compound. The agonistic properties of the most interesting compounds have been assessed by measuring their analgesic activity on mice (hot-plate test). Another result of the research was the identification of DMPP analogues, such as 3a (Ki = 90 nM) and 14b (Ki = 180 nM), that maintain affinity for the central nicotinic receptor when the ammonium function is changed into an aminic one and are therefore possible leads for drug development in neurodegenerative diseases.