197658-50-7

Basic information

• Product Name: [S-(R*,R*)]-1,3,4,5-Tetrahydro-3-[(1-phenylethyl)amino]-2H-1-benzazepin-2-one
• Synonyms: (3S)-1,3,4,5-Tetrahydro-3-[[(1S)-1-phenylethyl]amino]-2H-1-benzazepin-2-one;[S-(R*,R*)]-1,3,4,5-Tetrahydro-3-[(1-phenylethyl)amino]-2H-1-benzazepin-2-one;(3S)-3-[[(S)-1-Phenylethyl]amino]-1,3,4,5-tetrahydro-2H- 1-benzazepin-2-one;(3S)-3-[[(S)-1-Phenylethyl]amino]-1,3,4,5-tetrahydro-2H- 1-benzazepin-2-one,99%e.e.
• CAS NO: 197658-50-7
• Molecular Formula: C₁₈H₂₀N₂O
• Molecular Weight: 280.3642
• Mol File: 197658-50-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 185-188℃
• Boiling Point: 473℃
• Flash Point: 172℃
• Appearance: /
• Density: 1.15
• Storage Temp.: 2-8°C
• CAS DataBase Reference: [S-(R*,R*)]-1,3,4,5-Tetrahydro-3-[(1-phenylethyl)amino]-2H-1-benzazepin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: [S-(R*,R*)]-1,3,4,5-Tetrahydro-3-[(1-phenylethyl)amino]-2H-1-benzazepin-2-one(197658-50-7)
• EPA Substance Registry System: [S-(R*,R*)]-1,3,4,5-Tetrahydro-3-[(1-phenylethyl)amino]-2H-1-benzazepin-2-one(197658-50-7)

Safety Data

• Hazardous Substances Data: 197658-50-7(Hazardous Substances Data)

Usage

Description

[S-(R,R)]-1,3,4,5-Tetrahydro-3-[(1-phenylethyl)amino]-2H-1-benzazepin-2-one, commonly known as (-)-Apomorphine, is a potent dopamine agonist with significant applications in the medical field. It is characterized by its ability to stimulate dopamine receptors in the brain, which makes it a valuable compound for treating various conditions related to dopamine deficiency.

Uses

Used in Neurology:
(-)-Apomorphine is used as a therapeutic agent for treating motor fluctuations in patients with Parkinson's disease. Its application is based on its ability to alleviate symptoms such as muscle stiffness, tremors, and slow movement by stimulating dopamine receptors in the brain.
Used in Erectile Dysfunction Treatment:
(-)-Apomorphine is also being studied for its potential use as a treatment for erectile dysfunction. The application is due to its effects on dopamine receptors, which may help improve sexual function in certain cases.
Used in Addiction Treatment:
(-)-Apomorphine has shown promise in the treatment of addiction, particularly due to its interaction with dopamine receptors, which play a role in the reward system of the brain.
Used in Psychiatric Disorders:
Additionally, (-)-Apomorphine has been explored for its potential applications in treating psychiatric disorders, where dopamine imbalances may be a contributing factor.

Upstream product

• 86499-96-9 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 
• 197658-51-8 3-((S)-1-Phenyl-ethylamino)-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 

Downstream Products

• 109010-60-8 tert-butyl (3S)-3-amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetate 

Relevant articles and documents

Asymmetric synthesis of N-substituted α-aminobenzlactam via crystallization-induced asymmetric transformation of covalent diastereomer

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