19801-34-4

Basic information

• Product Name: S-ETHYL N-PHENYLISOTHIOUREA
• Synonyms: 2-Ethyl-1-phenyl-2-thio-pseudourea;N-Phenyl-carbaMiMidothioic Acid Ethyl Ester
• CAS NO: 19801-34-4
• Molecular Formula: C₉H₁₂N₂S
• Molecular Weight: 180.27
• Product Categories: Nitric Oxide Reagents
• Mol File: 19801-34-4.mol

Chemical Properties

• Boiling Point: 309.4°C at 760 mmHg
• Flash Point: 140.9°C
• Appearance: /
• Density: 1.09g/cm³
• Vapor Pressure: 0.000641mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: S-ETHYL N-PHENYLISOTHIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: S-ETHYL N-PHENYLISOTHIOUREA(19801-34-4)
• EPA Substance Registry System: S-ETHYL N-PHENYLISOTHIOUREA(19801-34-4)

Safety Data

• Hazardous Substances Data: 19801-34-4(Hazardous Substances Data)

Usage

Description

S-Ethyl N-Phenylisothiourea is an organic compound with the chemical formula C8H10N2S. It is a dark red, low melting solid that has been identified for its potent inhibitory effects on nitric oxide synthetase, an enzyme involved in various physiological and pathological processes.

Uses

Used in Pharmaceutical Research:
S-Ethyl N-Phenylisothiourea is used as a research compound for its ability to inhibit the human neuronal constitutive and inducible isoforms of nitric oxide synthetase. This makes it a valuable tool in studying the role of nitric oxide in various diseases and conditions, as well as in the development of potential therapeutic agents targeting this enzyme.
Used in Neurological Applications:
In the field of neurology, S-Ethyl N-Phenylisothiourea is used as a neuroprotective agent due to its inhibitory effects on nitric oxide synthetase. This application is particularly relevant in the study and treatment of neurodegenerative diseases, where nitric oxide is known to play a role in neuronal damage and cell death.
Used in Cardiovascular Research:
S-Ethyl N-Phenylisothiourea is also used in cardiovascular research, as nitric oxide synthetase plays a crucial role in the regulation of vascular tone and blood pressure. By inhibiting this enzyme, researchers can better understand its impact on cardiovascular health and develop potential treatments for conditions such as hypertension and atherosclerosis.
Used in Competitive Binding Studies:
Due to its ability to bind competitively with L-Arginine, S-Ethyl N-Phenylisothiourea is used in studies involving the investigation of enzyme kinetics and the development of novel inhibitors with improved selectivity and potency. This application is particularly relevant in the fields of medicinal chemistry and drug design.

InChI:InChI=1/C9H12N2S/c1-2-12-9(10)11-8-6-4-3-5-7-8/h3-7H,2H2,1H3,(H2,10,11)