198904-53-9

Basic information

• Product Name: 4-(1,3-THIAZOL-2-YL)BENZALDEHYDE
• Synonyms: 4-(1,3-THIAZOL-2-YL)BENZALDEHYDE;4-THIAZOL-2-YL-BENZALDEHYDE;2-(4-Formylphenyl)thiazole-4-carboxylic acid;2-(4-Formylphenyl)thiazole-5-carboxylic acid;4-(5-Nitrothiazol-2-yl)benzaldehyde;4-THIAZOL-2-YL-BENZALDEHYDE, 95+%
• CAS NO: 198904-53-9
• Molecular Formula: C₁₀H₇NOS
• Molecular Weight: 189.23
• Product Categories: Aldehydes;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 198904-53-9.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 350.298 °C at 760 mmHg
• Flash Point: 165.655 °C
• Appearance: /
• Density: 1.269 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.645
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-(1,3-THIAZOL-2-YL)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1,3-THIAZOL-2-YL)BENZALDEHYDE(198904-53-9)
• EPA Substance Registry System: 4-(1,3-THIAZOL-2-YL)BENZALDEHYDE(198904-53-9)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 198904-53-9(Hazardous Substances Data)

Usage

General Description

4-(1,3-thiazol-2-yl)benzaldehyde is a chemical compound with the molecular formula C10H7NOS. It is classified as an aldehyde, containing a benzene ring attached to a thiazole ring. 4-(1,3-THIAZOL-2-YL)BENZALDEHYDE is commonly used in the production of pharmaceuticals and agrochemicals, as well as in organic synthesis. It is known for its strong aromatic and fruity odor, and is often used as a flavoring agent in the food industry. Additionally, 4-(1,3-thiazol-2-yl)benzaldehyde has been studied for its potential medicinal properties, including its antimicrobial and anticancer activities. Due to its versatile applications and unique chemical structure, this compound is of interest to researchers in various fields.

InChI:InChI=1/C10H7NOS/c12-7-8-1-3-9(4-2-8)10-11-5-6-13-10/h1-7H

Upstream product

• 3034-53-5 2-bromo-1,3-thiazole 
• 24856-58-4 1,1-dimethoxy-1-(4-bromophenyl)methane 
• 87199-17-5 4-formylphenylboronic acid, 
• 3034-52-4 2-chlorothiazole 
• 1122-91-4 4-bromo-benzaldehyde 
• 389630-95-9 (thiazol-2-yl)boronic acid 

Downstream Products

• 210114-78-6 {3-[(4-thiazol-2-yl-benzylamino)-methyl]-phenoxy}-acetic acid tert-butyl ester 
• 266369-49-7 4-(1,3-Thiazol-2-yl)benzoic acid 
• 1010702-53-0 {(S)-2,2-dimethyl-1-[N'-(4-thiazol-2-ylbenzyl)hydrazinocarbonyl]propyl}carbamic acid methyl ester 
• 454678-91-2 (4-(thiazol-2-yl)phenyl)methanol 
• 1395472-42-0 1-(3-(1H-tetrazol-5-yl)phenyl)-4-(4-brombenzoyl)-3-hydroxy-5-(4-(thiazol-2-yl)phenyl)-1H-pyrrol-2(5H)-one 
• 1395472-38-4 1-(3-(1H-tetrazol-5-yl)phenyl)-3-hydroxy-4-(4-methoxybenzoyl)-5-(4-(thiazol-2-yl)phenyl)-1Hpyrrol-2(5H)-one 
• 1395472-35-1 1-(3-(1H-tetrazol-5-yl)phenyl)-4-benzoyl-3-hydroxy-5-(4-(thiazol-2-yl)phenyl)-1H-pyrrol-2(5H)-one 
• 1395472-39-5 5-(3-(4-bromobenzoyl)-4-hydroxy-5-oxo-2-(4-(thiazol-2-yl)phenyl)-2,5-dihydro-1H-pyrrol-1-yl)-2-hydroxybenzoic acid 
• 1395472-16-8 2-hydroxy-5-(3-hydroxy-4-(4-methoxybenzoyl)-2-oxo-5-(4-(thiazol-2-yl)phenyl)-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid 
• 1395472-40-8 3-(3-(4-brombenzoyl)-4-hydroxy-5-oxo-2-(4-(thiazol-2-yl)phenyl)-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid 
• 1395472-41-9 4-(3-(4-brombenzoyl)-4-hydroxy-5-oxo-2-(4-(thiazol-2-yl)phenyl)-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid 
• 1395472-37-3 3-(3-hydroxy-4-(4-methoxybenzoyl)-2-oxo-5-(4-(thiazol-2-yl)phenyl)-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid 
• 1395472-26-0 4-(3-hydroxy-4-(4-methoxybenzoyl)-2-oxo-5-(4-(thiazol-2-yl)phenyl)-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid 
• 1395472-33-9 3-(3-benzoyl-4-hydroxy-5-oxo-2-(4-(thiazol-2-yl)phenyl)-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid 

Relevant articles and documents

BENZIMIDAZOLE COMPOUNDS AND USE THEREOF FOR TREATING ALZHEIMER'S DISEASE OR HUNTINGTON'S DISEASE

Benzimidazole compounds of formula (I), shown below, are disclosed. The compounds are potent human glutaminyl cyclase inhibitors. Also disclosed is a pharmaceutical composition containing one of these compounds and a pharmaceutical acceptable carrier, as well as a method of treating Alzheimer's disease or Huntington's disease by administering to a subject in need thereof an effective amount of such a compound.

COMPOUND USED AS AUTOPHAGY REGULATOR, AND PREPARATION METHOD THEREFOR AND USES THEREOF

It is related to compounds used as autophagy modulators and a method for preparing and using the same, specifically providing a compound of general formula (I), or pharmaceutically acceptable salts thereof, which is a type of autophagy modulators, particularly mammalian ATG8 homologues modulators.

Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity

Poly(adenosine 5′-diphosphate-ribose) polymerase (PARP) inhibitors are a class of anticancer drugs that block the catalytic activity of PARP proteins. Optimization of our lead compound 1 ((Z)-2-benzylidene-3-oxo-2,3-dihydrobenzofuran-7-carboxamide; PARP-1 IC50 = 434 nM) led to a tetrazolyl analogue (51, IC50 = 35 nM) with improved inhibition. Isosteric replacement of the tetrazole ring with a carboxyl group (60, IC50 = 68 nM) gave a promising new lead, which was subsequently optimized to obtain analogues with potent PARP-1 IC50 values (4-197 nM). PARP enzyme profiling revealed that the majority of compounds are selective toward PARP-2 with IC50 values comparable to clinical inhibitors. X-ray crystal structures of the key inhibitors bound to PARP-1 illustrated the mode of interaction with analogue appendages extending toward the PARP-1 adenosine-binding pocket. Compound 81, an isoform-selective PARP-1/-2 (IC50 = 30 nM/2 nM) inhibitor, demonstrated selective cytotoxic effect toward breast cancer gene 1 (BRCA1)-deficient cells compared to isogenic BRCA1-proficient cells.