20033-96-9

Basic information

• Product Name: 1H-Benzimidazole-2-methanol,5-chloro-alpha-methyl-(9CI)
• Synonyms: 1H-Benzimidazole-2-methanol,5-chloro-alpha-methyl-(9CI);1-(5-chloro-1H-benzimidazol-2-yl)ethanol;1-(5-chloro-1H-benzo[d]imidazol-2-yl)ethanol;1-(6-chloro-1H-benzimidazol-2-yl)ethanol;MFCD00110960;1-(5-chloro-1H-1,3-benzodiazol-2-yl)ethan-1-ol
• CAS NO: 20033-96-9
• Molecular Formula: C₉H₉ClN₂O
• Molecular Weight: 196.64
• Product Categories: BENZIMIDAZOLE
• Mol File: 20033-96-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 171-173 °C(Solv: ethanol (64-17-5))
• Boiling Point: 421.8±25.0 °C(Predicted)
• Appearance: /
• Density: 1.423±0.06 g/cm3(Predicted)
• PKA: 10.19±0.10(Predicted)
• CAS DataBase Reference: 1H-Benzimidazole-2-methanol,5-chloro-alpha-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole-2-methanol,5-chloro-alpha-methyl-(9CI)(20033-96-9)
• EPA Substance Registry System: 1H-Benzimidazole-2-methanol,5-chloro-alpha-methyl-(9CI)(20033-96-9)

Safety Data

• Hazardous Substances Data: 20033-96-9(Hazardous Substances Data)

Usage

Chemical class

benzimidazole derivatives

Chlorinated derivative

yes (5-chloro)

Substitution position

2-methanol, alpha-methyl

Potential applications

pharmaceutical industry

Pharmacological properties

antiviral, anticancer, antimicrobial

Derivatives studied

therapeutic agents

Further research needed

pharmacological potential and safety profile.

Upstream product

• 849585-22-4 LACTIC ACID 
• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 1635-61-6 5-chloro-2-nitroaniline 

Downstream Products

• 1426544-51-5 2-[1-(5-chloro-1H-benzimidazol-2-yl)ethylidene]-N-cyclohexylhydrazine carbothioamide 
• 1426542-94-0 2-[1-(5-chloro-1H-benzimidazol-2-yl)ethylidene]-N-phenylhydrazine carbothioamide 
• 41510-16-1 1-(6-chloro-1H-1,3-benzodiazol-2-yl)ethan-1-one 
• 41510-16-1 1-(5-chloro-1H-benzo[d]imidazol-2-yl)-1-ethanone 
• 1251827-93-6 C₁₆H₁₀ClN₃O₃ 
• 1251827-92-5 C₁₈H₁₅ClN₂O 

Relevant articles and documents

Synthesis and antimicrobial activity of some new pyrimidines of 6-chlorobenzimidazoles

A new series of pyrimidines of 6-chlorobenzimidazoles have been synthesized by the reaction of chalcone derivatives of 6-chlorobenzimidazole with guanidine nitrate in ethanol and aqueous solution of sodium hydroxide for evaluating them as potent antimicrobial agents. Results reveal that, compounds exhibited significant antibacterial and antifungal activities.

Compositions containing five-membered unsaturated heterocyclic structure of the α, β unsaturated ketone compound and its preparation method and application

The invention provides alpha, beta unsaturated ketone compounds containing benzo five-membered unsaturated heterocycle structures as well as a preparation method and an application and use of the compounds. The alpha, beta unsaturated ketone compounds containing the benzo five-membered unsaturated heterocycle structures have the structure of a formula (I). In addition, the invention further provides a method for preparing the compounds and a pharmaceutical composition containing the components as active components. In vitro activity tests show that the compounds provided by the invention show a remarkable inhibiting effect on tumor cells. Therefore, the invention lays a foundation for lucubrating and developing anti-tumor medicines in the future and meanwhile further provides a new technical means for treating tumor diseases.

Synthesis of some novel thiosemicarbazone derivatives having anti-cancer, anti-HIV as well as anti-bacterial activity

Some new thiosemicarbazones containing benzimidazole moiety have been synthesized and their ability to inhibit growth of 60 human cancer cell lines, in vitro replication of HIV virus strains as well as inhibition capacity for various bacterial strains have been evaluated. One compound 2-|l-(5-chloro-l//- benzimidazol-2-yl) ethylidene] N-phenylhydrazincarbothioamide (S2) (NSC 92491) has been selected for five dosage screening and shows remarkable anticancer activity along with good anti-HIV and anti-bacterial activities. The structures of all the compounds have been confirmed by FT-IR, NMR, and Mass spectra and by elemental analysis.