20035-32-9

Basic information

• Product Name: 4-BROMO-3-HYDROXYBENZALDEHYDE
• Synonyms: 4-BROMO-3-HYDROXYBENZALDEHYDE
• CAS NO: 20035-32-9
• Molecular Formula: C₇H₅BrO₂
• Molecular Weight: 201.02
• Mol File: 20035-32-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 131.5 °C
• Boiling Point: 265.03 °C at 760 mmHg
• Flash Point: 114.087 °C
• Appearance: White solid
• Density: 1.737 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 7.71±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-3-HYDROXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-3-HYDROXYBENZALDEHYDE(20035-32-9)
• EPA Substance Registry System: 4-BROMO-3-HYDROXYBENZALDEHYDE(20035-32-9)

Safety Data

• Hazardous Substances Data: 20035-32-9(Hazardous Substances Data)

Usage

General Description

4-Bromo-3-hydroxybenzaldehyde, also known as 116543-89-3 and Bromohydroxybenzaldehyde, is a chemical compound known for its bromine and aldehyde functions. Its molecular formula is C7H5BrO2. It is typically used in the field of organic synthesis and pharmaceutical manufacturing, often as an intermediate in the synthesis of other complex organic compounds. The compound is a solid at room temperature, usually appearing as a light-colored or white powder. Like many other similar compounds, it should be handled with care due to potential health hazards, including eye and skin irritation and harmful effects if inhaled or swallowed.

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 106291-80-9 methyl 4-bromo-3-hydroxybenzoate 
• 122-46-3 3-acetoxytoluene 
• 108-39-4 3-methyl-phenol 
• 2737-19-1 4-bromo-3-hydroxy-benzyl alcohol 

Downstream Products

• 132040-97-2 1-Bromo-4-dimethoxymethyl-2-methoxy-benzene 
• 132041-01-1 4-((2R,4R,5R,6R)-4,5-Bis-methoxymethoxy-6-methyl-tetrahydro-pyran-2-yl)-N,N-diethyl-3-methoxy-benzamide 
• 132041-17-9 4-((2R,4R,5R,6R)-4,5-Bis-methoxymethoxy-6-methyl-tetrahydro-pyran-2-yl)-N,N-diethyl-2-formyl-3-methoxy-benzamide 
• 132040-96-1 3-Benzenesulfonyl-5-((2R,4R,5S,6R)-4,5-dihydroxy-6-methyl-tetrahydro-pyran-2-yl)-4-methoxy-3H-isobenzofuran-1-one 
• 132041-15-7 4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-3-bromo-6-methyl-tetrahydro-pyran-2-yl)-3-methoxy-benzoic acid 
• 132040-99-4 4-((2S,3S,4S,5R,6R)-4,5-Bis-benzyloxy-3-bromo-2-hydroxy-6-methyl-tetrahydro-pyran-2-yl)-3-methoxy-benzoic acid 
• 132041-00-0 4-((2R,4R,5R,6R)-4,5-Bis-benzyloxy-6-methyl-tetrahydro-pyran-2-yl)-N,N-diethyl-3-methoxy-benzamide 
• 132041-14-6 4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-3-bromo-6-methyl-tetrahydro-pyran-2-yl)-N,N-diethyl-3-methoxy-benzamide 
• 132041-16-8 4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-3-bromo-6-methyl-tetrahydro-pyran-2-yl)-3-methoxy-benzoic acid benzotriazol-1-yl ester 
• 132041-03-3 5-((2R,4R,5S,6R)-4,5-Dihydroxy-6-methyl-tetrahydro-pyran-2-yl)-4-methoxy-3-phenylsulfanyl-3H-isobenzofuran-1-one 
• 906673-54-9 4-(4-bromo-3-formaldehydephenoxy)benzonitrile 
• 540779-38-2 ethyl (E)-4-bromo-3-hydroxycinnamate 
• 736992-51-1 ethyl (E)-3-[5-(adamant-1-yl)-2-(3-(tert-butoxycarbonylamino)propoxy)-4-hydroxy-2-methylbiphenyl-4-yl]acrylate 
• 540779-43-9 ethyl (E)-4-[3'-(1-adamantyl)-4'-hydroxyphenyl]-3-(3'-aminopropoxy)cinnamate 

Relevant articles and documents

THERAPEUTIC AGENT FOR INFLAMMATORY DISEASES, AUTOIMMUNE DISEASES, FIBROTIC DISEASES, AND CANCER DISEASES

A therapeutic agent for treating at least one disease selected from the group consisting of inflammatory diseases, autoimmune diseases, fibrotic diseases, and cancer diseases, comprising: at least one selected from the group consisting of a compound represented by the following general formula (1) and pharmacologically acceptable salts thereof as an active ingredient. [In the formula (1), R1 and R2 may be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a carboxy group, a cyano group, an optionally substituted C1-6 alkyl group et al.; R3 represents a hydrogen atom; R4 represents an optionally substituted 4- to 10-membered monocyclic heterocyclic group containing 1 to 4 heteroatoms selected from an oxygen atom, a nitrogen atom, and a sulfur atom; X represents a group represented by the following formula: -CH2-, - CH2-CH2-, -CH2-CH2-CH2-, or -CH2-O-CH2-; and Z represents a hydrogen atom or a hydroxyl group.]

Synthesizing method of 4-(4-bromo-3-aldehyde-phenoxyl)-benzonitrile

The invention provides a synthesizing method of 4-(4-bromo-3-aldehyde-phenoxyl)-benzonitrile. The synthesizing method comprises the following steps of using 3-methylphenol as the starting raw material, and reacting with acid anhydride to prepare 3-methyl-benzene ester; enabling the 3-methyl-benzene ester and sulfonyl chloride to react, so as to prepare a mixture of 3-chloromethyl-benzene ester and3-dichloromethyl-benzene ester; adding ulotropine, and hydrolyzing, so as to obtain 3-hydroxyl-benzaldehyde; performing brominating reaction, so as to obtain 4-bromo-3-hydroxyl-benzaldehyde; adding 4-fluorobenzonitrile, and performing condensation reaction, so as to obtain the 4-(4-bromo-3-aldehyde-phenoxyl)-benzonitrile. The synthesizing method has the advantages that the prices of the reactionraw materials are low, the obtaining is easy, the reaction steps are fewer, the production cost is low, the technology is simple, the product purity is high and reaches 99.0% or above, and the synthesizing method is suitable for industrialized production.

Mild, efficient, and regioselective monobromination of arylamines and phenols using [BBIm]Br3 as a new reagent

We report here an efficient method for the synthesis and characterization of the room-temperature ionic liquid 1,3-di-n-butylimidazolium tribromide ([BBIm]Br3) (2) and its application as an efficient reagent and solvent for regioselective bromination of arylamines and phenols under mild conditions. The bromination was carried out in the absence of organic solvents, and in most cases, the only extraction solvent needed was water. The spent 1,3-di-n-butylimidazolium bromide (1) was easily recycled.